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Interferon Alfa 2A

Latest prescription information about Interferon Alfa 2A. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Interferon Alfa 2A
Pronunciation : IN-ter-FEER-on ALfa
Trade Name(s): 
India- Alferon Vial, Inron-A Inj, Intalfa Vial, Lg Intermax Alpha Inj, Roferon-A Amp, Roferon-A Vial, Zavinex Inj.
International- Roferon-A.
Why it is prescribed (Indications) : 
This medication is prescribed for hairy cell leukemia (blood cancer), AIDS-related Kaposi's sarcoma (type of cancer that develops in connective tissues), recurrent or metastatic renal cell carcinoma (kidney cancer) and chronic myelogenous leukemia (cancer of white blood cells), hepatitis C, non-Hodgin’s lymphoma. It is an immuno modulator. It may work directly against tumor cells and viruses and help the immune system fight them.

When it is not to be taken (Contraindications): 


Contraindicated in patients with hypersensitivity, liver or heart disease, epilepsy, pregnancy.


When it is to be taken : 
SC/IM- Renal cell carcinoma- In an escalating dose of 3 million u 3 times/day over 10 to 12 weeks. Maintenance: 18 to 36 million 3times/week.
Hairy Cell Leukemia- Adults -IM/SC- Induction: 3million units/day, for 16 to 24weeks; Maintenance: 3million units 3times/week.
AIDS-Related Kaposi Sarcoma- Adults- IM/SC- Induction: 36 million units/day, for 10 to 12 weeks. Alternative induction: 3 million units for 3 days, then 9 million units for 3days, then 18 million units for 3days, then 36 million units daily for a total of 10 to 12 weeks.
Chronic Myelogenous Leukemia-Adults-IM/SC- 9 million units/day. Alternative regimen : 3 million units/day for 3 days, then 6 million units/day for 3 days, then 9 million units/day for the duration of therapy.
Chronic myeloid leukemia- SC/IM- 3 million units daily over 8 to 12 weeks.
Hepatitis C- SC/IM- 6 million units 3 times a week.
non-Hodgin’s lymphoma- SC/IM- 6 MIU/m ² from 22 to 26 of each 28 days cycle.
How it should be taken : 
It comes as a solution for injection, to be administered either under the skin or into the muscle by a healthcare provider.
Special Instruction : 
*Caution needed for patients with history of depression, seizures, compromised central nervous system function, heart disease, hypo or hyperthyroidism, diabetes, patients with impaired renal function, pregnancy and breastfeeding.
*It may case dizziness or drowsiness. Do not drive a car or operate machinery while taking this medication.
*It may cause high or low blood sugar, patients' may experience with the following symptoms: Increased thirst, headache, difficulty in concentrating, blurred vision, frequent urination, fatigue (weak, tired feeling), weight loss, vaginal and skin infections, decreased vision, nervousness, sweating, intense hunger, trembling, weakness, palpitations, and trouble speaking. Contact your healthcare provider immediately.
Side Effects : 
Most Common- Flu-like syndrome, elevated liver function tests and severe infections.
Central Nervous System- Dizziness, depression, tongue tingling, sleep disorder, confusion, ringing in the ear, brain disease, seizures, lack of co-ordination, suicidal tendencies and stroke.
Heart- Swelling of legs, low blood pressure, abnormal heart rhythm, palpitations and chest pain.
Skin- Rash, transient hair loss or thinning of the hair and excessive sweating or night sweats.
Endocrine- Low or high thyroid hormone and increased or decreased blood sugar level.
Gastrointestinal- Moderate potential for nausea and vomiting, taste loss, diarrhea, dry mouth, gum inflammation, loss of appetite, weight loss and inflammation of colon and /or pancreas.
Blood- Decrease in white blood cells and platelets, leading to risk of infection and bleeding.
Hypersensitivity- Severe allergic reactions and autoimmune diseases.
Musculoskeletal- Severe muscle pain in chronic myelogenous leukemia patients.
Genitourinary- Protein in urine and acute kidney failure.
Respiratory- Difficulty in breathing, cough, inflammation of nose and/or pharynx and drying of the oropharynx.
Eye- Visual disturbances and eye pain.
Other Precautions : 
*Monitor blood counts, blood sugar, blood pressure levels; heart, liver, kidney, thyroid and lung functions regularly while taking this medication.
Storage Conditions : 
Injection: Store in a refrigerator at 2-8°C. Do not freeze it.

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