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Idursulfase

Latest prescription information about Idursulfase. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Idursulfase
Pronunciation : EYE dur SUL fase
Therapeutic Classification : Enzyme Replacement Therapy
Trade Name(s): 
International- Elaprase.
Why it is prescribed (Indications) : 
This medication is a lysosomal enzyme, prescribed for Hunter syndrome. It provides a certain enzyme (iduronate-2-sulfatase) to the body.
When it is not to be taken (Contraindications): Hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
IV- The recommended dosage regimen is 0.5 mg/kg of body weight administered every week as an intravenous infusion.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare professional into the vein.
Warnings and Precautions : 
* Caution should be exercised in patients with history of fever, lung or breathing problems, respiratory tract infection, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.
Side Effects : 
Most Serious- Anaphylactic and allergic reactions.
Most Common- Irregular heart beat, blood clot in lungs, blue or purple coloration of the skin, respiratory failure, infection, joint pain, headache, fever, rash, itching, redness, hives and high blood pressure.
Central Nervous System- Uneasiness, anxiety and irritability.
Other Precautions : 
*Avoid excess dosage.
Storage Conditions : 
Store it in refrigerator (2°C to 8°C), do not freeze it.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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