Hydrochlorothiazide and Spironolactone - Drug Information

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General Information on Hydrochlorothiazide and Spironolactone

Generic Name : Hydrochlorothiazide and Spironolactone

Pronunciation : hye droe klor oh thye' a zide- speer on oh lak' tone

Latest prescription information about Hydrochlorothiazide and Spironolactone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y54.5 | Therapeutic Classification : Diuretics

Trade Names/Brand Names of Hydrochlorothiazide and Spironolactone

International- Aldactazide, Spironazide, Spirozide.

Why is Hydrochlorothiazide and Spironolactone Prescribed? (Indications)

This combination medication contains potassium-sparing diuretic and thiazide diuretic, prescribed for essential hypertension and fluid retention caused by various conditions, including heart disease. 

When should Hydrochlorothiazide and Spironolactone not to be taken? (Contraindications)

Contraindicated in patients with anuria, acute kidney impairment and hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Hydrochlorothiazide and Spironolactone?

Po- The recommended dose is 100mg (Hydrochlorothiazide 100mg and Spironolactone 100mg) in a single dose or in divided dose.

How should Hydrochlorothiazide and Spironolactone be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Hydrochlorothiazide and Spironolactone?

Caution should be exercised in patients with diabetes, gout, kidney or liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Avoid alcohol consumption.
Avoid exposure to sunlight; otherwise it may cause sunburn.
It may affect blood sugar level; monitor sugar level regularly.
Monitor liver function, kidney function, lung function, blood pressure, blood electrolytes and fasting blood glucose levels regularly while taking this medication.

What are the side effects of Hydrochlorothiazide and Spironolactone?

   Body as a whole : Weakness.
   Heart : Low blood pressure.
   Gastrointestinal : Inflammation of pancreas, jaundice, diarrhea, vomiting, cramping, constipation, gastric irritation, nausea and loss of appetite.
   Blood : Anemia and decrease in white blood cells/platelets.
   Hypersensitivity : Shock, respiratory distress including lung inflammation/swelling, photosensitivity, fever, hives, rash and bruising.
   Metabolic : Electrolyte imbalance.
   Musculoskeletal : Muscle spasm.
   Central Nervous system : Vertigo, tingling, dizziness, headache and restlessness.
   Genitourinary : Kidney failure.
   Skin : Redness and itching.
   Eye : Blurred vision.

What are the other precautions for Hydrochlorothiazide and Spironolactone?

Avoid excess dosage.

What are the storage conditions of Hydrochlorothiazide and Spironolactone?

Store it in room temperature (25C).

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