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Hydrochlorothiazide and Spironolactone

Latest prescription information about Hydrochlorothiazide and Spironolactone. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Hydrochlorothiazide and Spironolactone
Pronunciation : hye droe klor oh thye' a zide- speer on oh lak' tone
Therapeutic Classification : Diuretics
ICD Code : Y54.5
Trade Name(s): 
International- Aldactazide, Spironazide, Spirozide.
Why it is prescribed (Indications) : 
This combination medication contains potassium-sparing diuretic and thiazide diuretic, prescribed for essential hypertension and fluid retention caused by various conditions, including heart disease. 
When it is not to be taken (Contraindications): Contraindicated in patients with anuria, acute kidney impairment and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Po- The recommended dose is 100mg (Hydrochlorothiazide 100mg and Spironolactone 100mg) in a single dose or in divided dose.
How it should be taken : 
It comes as a tablet to take by mouth, with or without food.
Warnings and Precautions : 
* Caution should be exercised in patients with diabetes, gout, kidney or liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
* Avoid alcohol consumption.
* Avoid exposure to sunlight; otherwise it may cause sunburn.
* It may affect blood sugar level; monitor sugar level regularly.
* Monitor liver function, kidney function, lung function, blood pressure, blood electrolytes and fasting blood glucose levels regularly while taking this medication.
Side Effects : 
Body as a whole - Weakness.
Heart - Low blood pressure.
Gastrointestinal - Inflammation of pancreas, jaundice, diarrhea, vomiting, cramping, constipation, gastric irritation, nausea and loss of appetite.
Blood - Anemia and decrease in white blood cells/platelets.
Hypersensitivity - Shock, respiratory distress including lung inflammation/swelling, photosensitivity, fever, hives, rash and bruising.
Metabolic - Electrolyte imbalance.
Musculoskeletal - Muscle spasm.
Central Nervous system - Vertigo, tingling, dizziness, headache and restlessness.
Genitourinary - Kidney failure.
Skin - Redness and itching.
Eye - Blurred vision.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it in room temperature (25°C).

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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