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Histrelin acetate

Latest prescription information about Histrelin acetate. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Histrelin acetate
Pronunciation : hiss-TREL-in AS-e-tate
Trade Name(s): 
International- Vantas, Supprelin LA.
Why it is prescribed (Indications) : 
This medication is an analog of gonadotropin-releasing hormone (GnRH), prescribed for children with central precocious puberty and also for hormone-sensitive cancers of the prostate in men and uterine fibroids in women.

When it is not to be taken (Contraindications): 


Contraindicated in pregnant women and patients with known hypersensitivity.

Pregnancy Category :

A B C D X
Category X : Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.


When it is to be taken : 
Adults (Supprelin LA – 2 years of age and older)- Subcutaneous- 1 implant (50 mg) for 12 months.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider under the skin.
Special Instruction : 
* Caution should be exercised in patients with any allergy, who are taking other medications, children, during pregnancy and breastfeeding.
* Avoid using contaminated solution of this medication.
* It should not be used in children aged less than 2 years.
Side Effects : 
Heart- Palpitations and irregular heart beat.
Central Nervous System- Fatigue, headache, sleeplessness, decreased libido, depression, dizziness, irritability, lethargy, uneasiness, tremor and weakness.
Skin- Increased sweating, night sweats and itching.
Gastrointestinal- Constipation, abdominal discomfort and nausea.
Genitourinary- Kidney impairment, impotence, breast enlargement in males, blood in urine, urinary frequency, breast pain, breast tenderness, painful urination, genital itching and kidney stones.
Blood- Anemia, bruising and blood clots.
Liver- Liver disorder.
Local- Implant-site reactions, scar, pain and wound infections.
Metabolic- Increased weight, fluid retention, increased appetite and swelling in the extremities.
Musculoskeletal- Aggravated back pain, bone pain, muscle twitching, neck pain and pain in limb.
Respiratory- Difficulty in breathing.
Miscellaneous- Hot flashes, exacerbated pain, feeling cold and flushing.
Other Precautions : 
*Avoid excess dosage.
Storage Conditions : 
Store it in refrigerator (2-8ºC).

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