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Hepatitis A Vaccine

Latest prescription information about Hepatitis A Vaccine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Hepatitis A Vaccine
Pronunciation : HEP a TYE tis
Therapeutic Classification : Immunizing Agents
ICD Code : Y59.0
Trade Name(s): 
India- Avaxim, Avaxim 80U, Biovac-A Inj, Twinrex Junior Inj, Twinrix Inj, Harvixinj.
International- Havrix, Vaqta.
Why it is prescribed (Indications) : 
This medication is a vaccine given to individuals over 2 years of age to prevent hepatitis A infection. It stimulates the body to produce antibodies against hepatitis A infection. 
When it is not to be taken (Contraindications): 
Severe immunodeficiency, allergic reaction (e.g., anaphylaxis) after a previous dose of any hepatitis A-containing vaccine, or to any component of Hepatitis A vaccine including neomycin.
Malignant disease being treated with chemotherapy or radiotherapy and for at least 6 months after stopping treatment.
Patients with compromised immune system such as those on high-dose systemic corticosteroids, immunosuppressant or HIV positive.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
IM- Single dose of 0.5 or 1 ml depending on the product and patient's age. Give booster dose 6-12 months after the initial dose. Give via subcutaneous administration in haemophiliacs.
How it should be taken : 
It comes as a solution for injection administered by a health care provider into the large muscle.
Warnings and Precautions : 
*Hepatitis A vaccine becomes effective after a period of at least 2 weeks. A second dose is administered 6 to 12 months after the first dose.
*It should not be used in children younger than 12 months old.
*Alcohol or disinfectant used for cleaning the skin prior to injection should be allowed to evaporate completely before vaccination to prevent vaccine inactivation.
*Caution needed for patients with history of illnesses or infections, blood disorders, immune system disorders, any allergies, pregnancy and breastfeeding.
Side Effects : 
Central Nervous System- Headache and tiredness.
Local- Redness, soreness, swelling, redness, or warmth at the injection site and indurations at injection site.
Miscellaneous- Loss of appetite, mild fever, nausea and transient soreness.
Other Precautions : 
*For IM injection only. Not for IV or intradermal administration.
Storage Conditions : 
It is usually handled and stored by a health care provider.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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