Why it is prescribed :
This medication is an anticoagulant, prescribed for deep venous thrombosis, arterial embolism and pulmonary embolism. It is also used for prevention of blood clot in heart surgery. It decreases the clotting ability of the blood.
When it is not to be taken (Contraindications):
Contraindicated in patients with uncontrolled active bleeding, unexplained bruising, or low blood platelets, uncontrolled high blood pressure, and hypersensitivity.
Category C :
Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.
Dosage & When it is to be taken (Indications):
Adult: IV- Loading dose: 5,000 u, then 1,000-2,000 u/hr.
How it should be taken :
It comes as a solution for injection to be administered by a healthcare provider into the vein.
Warnings and Precautions :
Caution should be exercised in patients with history of heart problems, high blood pressure, menstrual problems, bleeding problems, ulcer, recent injury, blood disorder, liver or kidney disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may reduce platelet counts; avoid injury or bruising.
♦Patient may develop with increased risk of Heparin-induced Thrombocytopenia (HIT).
Side Effects :
Irritation, redness, or mild pain at the injection site.
Fever, headache, chills, nausea, vomiting, constipation, nosebleed, bruising, slight blood in urine, skin necrosis (SC inj), osteoporosis, and hair loss.
Other Precautions :
Avoid excess dosage.
Storage Conditions :
Store at 20°C.
Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.
♦ Safety Labeling Changes Approved By FDA