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Furosemide and Spironolactone

Latest prescription information about Furosemide and Spironolactone. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Furosemide and Spironolactone
Therapeutic Classification : Diuretics
ICD Code : Y54.5
Trade Name(s): 
India- Aldostix, Amifru-S, Aquamide, Fruselac, Fruselac-D, Lasilacton, Minilacton, Spiromide, Spirotic.
International- Lasilactone.
Why it is prescribed (Indications) : 
This combination medication contains diuretics, prescribed for congestive heart failure and fluid retention. 
When it is not to be taken (Contraindications): Contraindicated in patients with hypersensitivity, anuria, low volume of fluid in the blood, low level of blood minerals, low blood pressure, kidney failure, Addison's disease, children, and lactation.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
Adult: PO- Per tab contains furosemide 20 mg and spironolactone 50 mg: 1-4 tabs/day.
How it should be taken : 
It comes as a tablet to take by mouth, with food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of enlarged prostate, liver impairment, any allergy, dehydration, who are taking other medications, during pregnancy.
* It may lead to dehydration; consult with your healthcare provider before taking this medication.
* It may cause fatigue and dizziness, do not drive a car or operate machinery while taking this medication.
* Monitor kidney function regularly while taking this medication.
Side Effects : 
Most Common - Fluid and electrolyte imbalance, dehydration, nausea, diarrhea, blurred vision, headache, dizziness, drowsiness, low blood pressure, liver dysfunction, high blood sugar.
Genitourinary - Excretion of glucose into the urine, rarely bone marrow depression, breast enlargement in males, excessive hairiness, hoarseness, menstrual irregularities, loss of libido, impotence.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store in a cool, dry place, away from direct heat and light.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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