Fluorouracil - Drug Information

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General Information on Fluorouracil

Generic Name : Fluorouracil

Pronunciation : flure oh yoor' a sill

Latest prescription information about Fluorouracil. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y56.9 | Therapeutic Classification : Miscellaneous Dermatologicals

Why is Fluorouracil Prescribed? (Indications)

This medication is an antimetabolite, prescribed for certain types of cancer such as colon, rectal, breast, stomach and pancreatic cancer.  It works by blocking the growth of certain cells.

When should Fluorouracil not to be taken? (Contraindications)

Contraindicated in patients with severe infection, who are taking sorivudine and hypersensitivity.

Pregnancy Category

A B C D X

Category D :

There is an evidence of fetal risk based on adverse reaction data, but potential benefits may allow the drug to be used in pregnant women despite risks.

What is the dosage of Fluorouracil?

PO- The recommended dose is 1gm on alternate days, then 1 gm weekly. IV- 12mg/kg/day for 4 days.
Topical: 0.5 -5%cream- Apply 1-2 times/day for 2-4 week.

How should Fluorouracil be taken?

It comes as a tablet to take by mouth. It also comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Fluorouracil?

Caution should be exercised in patients with liver or kidney impairment, any allergy, who are taking other medications, during pregnancy and breast-feeding.
Avoid contact with people who have any infection.
It may reduce platelet counts; avoid bruising or bleeding.
Avoid vaccination while taking this medication.

What are the side effects of Fluorouracil?

   Most Common : Burning, crusting, skin inflammation, erosions, redness of the skin, pigmentation, irritation, pain, photosensitivity, itching, scar, rash, soreness and ulceration.
   Central Nervous System : Emotional upset, sleeplessness and irritability.
   Gastrointestinal : Taste perversion and mouth ulcer.
   Blood : Eosinophilia, decrease in platelets and toxic granulation.
   Skin : Hair loss, blistering, scaling, swelling, tenderness and hives.
   Special Senses : Eye irritation, increased tears and nose irritation.
   Miscellaneous : Herpes simplex.

What are the other precautions for Fluorouracil?

Avoid excess dosage.

What are the storage conditions of Fluorouracil?

Store it at room temperature (25�C), and in an airtight container. Keep away from children.

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