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Medindia » Medication Manual » Febuxostat

Febuxostat

Updated on : November - 2012

Latest prescription information about Febuxostat. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Generic Name : Febuxostat

Pronunciation : feb ux' oh stat

Therapeutic Classification : Anti- Gout Medications

ICD Code : Y54.8

Trade Name(s):
India- Goustat, Febucip, Feboxa, Goustat (80 mg), Feburic, Fabulas, Feboxa (80 mg), Febucip (80 mg), Fegout.
International- Uloric.

Why it is prescribed (Indications) :
This medication is a xanthine oxidase (XO) inhibitor, prescribed for gout and hyperuricemia (high level of uric acid in blood). It decreases the amount of uric acid in blood.

When it is not to be taken (Contraindications):
Contraindicated in patients treated with azathioprine, mercaptopurine or theophylline.

♦ Pregnancy Category :

A B C D X

Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken :
PO- The recommended dose is 40 to 80mg, once daily.

How it should be taken :
It comes as a tablet to take by mouth with or without food.

Warnings and Precautions :
* Caution should be exercised in patients with history of liver, kidney diseases, chest pain, cancer, stroke, elderly, children, pregnancy, and breastfeeding.
* Caution should be exercised in patients who have undergone organ transplantation (kidney, liver, heart and lung).
* If condition worsens, stop the medication immediately.

Side Effects :
Most Common- Swelling in the face, lips, tongue or throat regions, sweating, general illness and loss of appetite.
Skin- Allergic reactions.
Respiratory - Difficulty in breathing.
Heart- Chest pain and heaviness in the chest region.
Gastrointestinal - Nausea and stomach pain.
Central Nervous System- Headache and confusion.
Eye- Vision problems.
Genitourinary- Dark colored urine.
Less Common- Anemia, pain, swelling in the joint regions, stroke and inflammation of liver.
Liver- ♦ Liver failure and jaundice.

Other Precautions :
* Patient may develop with severe blood clot events; if so contact your healthcare provider immediately.

Storage Conditions :
Store it at room temperature.

♦ Safety Labeling Changes Approved By FDA