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Famotidine and Ibuprofen

Latest prescription information about Famotidine and Ibuprofen. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Famotidine and Ibuprofen
Pronunciation : fam OH ti deen and EYE bue PROE fen
Therapeutic Classification : Antirheumatics
ICD Code : Y45.4
Trade Name(s): 
International- Duexis.
Why it is prescribed (Indications) : 
This combination medication contains histamine blocker and nonsteroidal anti-inflammatory drug (NSAID), prescribed for relieving the symptoms of rheumatoid arthritis and osteoarthritis.  
When it is not to be taken (Contraindications): Contraindicated in patients who have experienced asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs, perioperative pain in the setting of coronary artery bypass graft (CABG) surgery, late stages of pregnancy, and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Usual Adult Dose for Osteoarthritis: Famotidine-ibuprofen 26.6 mg-800 mg: 1 tablet orally 3 times daily.
Usual Adult Dose for Rheumatoid Arthritis: Famotidine-ibuprofen 26.6 mg-800 mg: 1 tablet orally 3 times daily.
How it should be taken : 
It comes as a tablet to take by mouth.
Warnings and Precautions : 
* Caution should be exercised in patients with history of Crohn's disease, inflammatory bowel disease, intestinal ulcer, heart attack, stroke, blood clot, congestive heart failure, high blood pressure, stomach ulcer, asthma, heart, liver or kidney disease, systemic lupus erythematosus (SLE), bleeding disorder, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause life-threatening heart or circulation problems incase of long-term use. So avoid long-term use of this medication.
Side Effects : 
Central Nervous system - Numbness, weakness, headache, confusion, vision problem, speech disorder, severe headache, tingling, seizures and blurred vision.
Gastrointestinal - Black, bloody, or tarry stools, nausea, upper stomach pain, loss of appetite, stomach upset , vomiting, diarrhea, and constipation.
Respiratory - Coughing up blood, trouble in breathing, shortness of breath.
Metabolic - Rapid weight gain, jaundice.
Skin - Increased sweating.
Heart - Chest pain or discomfort, and rapid heart rate.
Miscellaneous - Back pain, neck stiffness, chills, increased sensitivity to light, less urination.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store the medication as directed by your physician.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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