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Etonogestrel

Latest prescription information about Etonogestrel. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Etonogestrel
Pronunciation : e-TOE-noe-jes-trel
Therapeutic Classification : Hormones
ICD Code : Y42
Trade Name(s): 
International- Implanon, Nexplanon.
Why it is prescribed (Indications) : 
This medication is a progestin, prescribed for preventing pregnancy. It works by preventing ovulation.
When it is not to be taken (Contraindications): 
Contraindicated in patients with cancer of the breast, acute porphyrias, abnormal vaginal bleeding, liver impairment, blood clots, and hypersensitivity.

Pregnancy Category :

A B C D X
Category X : Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Dosage & When it is to be taken : 
Implant - a single implant should be inserted between Day 1 and Day 5 of the menstrual cycle, , even if the woman is still bleeding.
How it should be taken : 
It comes as subdermal implant, to be inserted just under the skin of a woman's upper arm.
Warnings and Precautions : 
* Caution should be exercised in patients with history of active blood clot in the vein, migraine, cervical cancer, stroke, angina or heart attack, smoking, high cholesterol, high blood pressure, diabetes, liver cancer, cirrhosis, gallbladder disease, jaundice, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* A well-trained healthcare provider should administer it.
* Rule out pregnancy before inserting the implant.
* No preceding hormonal contraceptive use in the past month.
Side Effects : 
Most Common - Bleeding irregularities, emotional lability, weight increase, headache, pimples, depression, breast pain, abdominal pain, inflammation of pharynx, white dischage, influenza-like symptoms, dizziness, painful menstruation, back pain, nausea, pain, nervousness, depression, hypersensitivity, insertion site pain.
Gastrointestinal - Constipation, diarrhea, flatulence, vomiting.
General - Fluid retention, fatigue, implant site reaction, fever.
Infections - Urinary tract infection.
Investigations- Increase in blood pressure, decreased weight.
Metabolic - Increased appetite.
Musculoskeletal - Joint pain, muscle pain.
Central Nervous system - Convulsions, migraine, and drowsiness.
Psychiatric - Anxiety, sleeplessness, decreased libido.
Genitourinary - Painful urination, breast discharge, breast enlargement, ovarian cyst, genital itching, vulvovaginal discomfort.
Skin - Angioedema and/or aggravation of hereditary angioedema, hair loss, hypertrichosis, itching, rash, increased sweating, hives.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store this medication as directed by your physician.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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