Eplerenone - Drug Information

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General Information on Eplerenone

Generic Name : Eplerenone

Pronunciation : eh-PLER-en-one

Latest prescription information about Eplerenone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Aldosterone Antagonists

Trade Names/Brand Names of Eplerenone

Why is Eplerenone Prescribed? (Indications)

This medication is a mineral corticoid receptor antagonist, prescribed for high blood pressure and heart attack. It blocks the action of aldosterone, which aids in the regulation of blood pressure. 

When should Eplerenone not to be taken? (Contraindications)

Contraindicated in people with severe kidney or liver problem, co-administration with ketoconazole, itraconazole, serum potassium greater than 5.5 mEq/L, type 2 diabetes with microalbuminuria, serum creatinine greater than 2 mg/dL in men or greater than 1.8 mg/dl in women, Creatinine Clearance Rate (Ccr) 30 mL/min or less.

Pregnancy Category

A B C D X

Category B :

Animal studies have failed to demonstrate a risk to the fetus and appropriate studies on pregnant women are lacking.

What is the dosage of Eplerenone?

Adults: PO- Start with 25 mg every day and titrate to target dose of 50 mg every day within 4 weeks as tolerated by the patient.

How should Eplerenone be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Eplerenone?

Caution should be exercised in patients with history of diabetes, gout, liver or kidney disease, increased potassium level in blood, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

What are the side effects of Eplerenone?

  Metabolic: Increase in blood cholesterol and sugar level.
  Gastrointestinal: Diarrhea and abdominal pain.
  Genitourinary: Presence of albumin in urine.
  Respiratory: Cough.
  Central Nervous System: Dizziness.
  Body as a Whole: Fatigue and influenza-like symptoms.

What are the other precautions for Eplerenone?

Avoid alcohol consumption.

What are the storage conditions of Eplerenone?

Store it at room temperature (25C).

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