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Eplerenone - Drug Information

Generic Name : Eplerenone | Pronunciation : eh-PLER-en-one

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Latest prescription information about Eplerenone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Aldosterone Antagonists
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Trade Name(s): 


India : 



International : 

Inspra

Why it is prescribed (Indications) : 


This medication is a mineral corticoid receptor antagonist, prescribed for high blood pressure and heart attack. It blocks the action of aldosterone, which aids in the regulation of blood pressure. 

When it is not to be taken (Contraindications): 


Contraindicated in people with severe kidney or liver problem, co-administration with ketoconazole, itraconazole, serum potassium greater than 5.5 mEq/L, type 2 diabetes with microalbuminuria, serum creatinine greater than 2 mg/dL in men or greater than 1.8 mg/dl in women, Creatinine Clearance Rate (Ccr) 30 mL/min or less.

Pregnancy Category :

A B C D X

Category B :

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.


Dosage & When it is to be taken : 


Adults: PO- Start with 25 mg every day and titrate to target dose of 50 mg every day within 4 weeks as tolerated by the patient.

How it should be taken : 


It comes as a tablet to take by mouth, with or without food.

Warnings and Precautions : 

Caution should be exercised in patients with history of diabetes, gout, liver or kidney disease, increased potassium level in blood, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.


Side Effects : 


  Metabolic
- Increase in blood cholesterol and sugar level.

  Gastrointestinal
- Diarrhea and abdominal pain.

  Genitourinary
- Presence of albumin in urine.

  Respiratory
- Cough.

  Central Nervous System
- Dizziness.

  Body as a Whole
- Fatigue and influenza-like symptoms.


Other Precautions : 

Avoid alcohol consumption.


Storage Conditions : 

Store it at room temperature (25C).

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