This medication is a mineral corticoid receptor antagonist, prescribed for high blood pressure and heart attack. It blocks the action of aldosterone, which aids in the regulation of blood pressure.
Contraindicated in people with severe kidney or liver problem, co-administration with ketoconazole, itraconazole, serum potassium greater than 5.5 mEq/L, type 2 diabetes with microalbuminuria, serum creatinine greater than 2 mg/dL in men or greater than 1.8 mg/dl in women, Creatinine Clearance Rate (Ccr) 30 mL/min or less.
Adults: PO- Start with 25 mg every day and titrate to target dose of 50 mg every day within 4 weeks as tolerated by the patient.
It comes as a tablet to take by mouth, with or without food.
• Caution should be exercised in patients with history of diabetes, gout, liver or kidney disease, increased potassium level in blood, any allergy, who are taking other medications, during pregnancy and breastfeeding.
• It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
Increase in blood cholesterol and sugar level.
• Gastrointestinal: Diarrhea and abdominal pain.
• Genitourinary: Presence of albumin in urine.
• Respiratory: Cough.
• Central Nervous System: Dizziness.
• Body as a Whole: Fatigue and influenza-like symptoms.
Avoid alcohol consumption.
Store it at room temperature (25°C).
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