Generic Name : Entacapone Pronunciation : en-TAK-a-pone Therapeutic Classification : Antiparkinson Agents ICD Code : Y46.7
India- Adcapone Tab, Entacom Tab, Syncapone Tab - Carbidopa + Entacapone + Levo-Dopa .
International- Comtan. Why it is prescribed (Indications) :
This medication is catechol-o-methyltransferase (COMT) inhibitor, used as an adjunct to levodopa/carbidopa to treat patients with idiopathic Parkinson‘s disease. It is used during the later stages when the patient does not respond well to levodopa/carbidopa. It increases the levels of levodopa/carbidopa in the brain, enhancing its effectiveness. When it is not to be taken (Contraindications):
Dosage & When it is to be taken :
PO: The recommended dose is 200 mg with each levodopa/carbidopa up to a maximum of 1600 mg/day. How it should be taken :
It comes as a tablet to take by mouth. Warnings and Precautions :
*It may cause dizziness, lightheadedness, or fainting; do not drive a car or operate machinery, while taking this medication.
*Avoid alcohol consumption.
*It may lead to an increase in involuntary movements.
Caution needed during pregnancy and breastfeeding. Side Effects :
Most Common- Diarrhea, movement disorder, nausea, abdominal pain.
Skin - Sweating increased
Central Nervous System - Involuntary movements, increased or decreased movements, dizziness, anxiety, drowsiness, agitation, and worsening of condition.
ENT- Taste perversion
Gastrointestinal - Nausea, diarrhea, abdominal pain, constipation, vomiting, dry mouth, indigestion, flatulence, gastritis.
Respiratory- Difficulty in breathing.
Blood- Easy bruising
Genitourinary- Urine discoloration
Body as a whole- Back pain, fatigue, weakness
Miscellaneous- Bacterial infection.
*Stop this medication if unwanted symptoms developed. Storage Conditions :
Store it at room temperature and in airtight container. Keep away from children
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