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Entacapone

Latest prescription information about Entacapone. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Entacapone
Pronunciation : en-TAK-a-pone
Therapeutic Classification : Antiparkinson Agents
ICD Code : Y46.7
Trade Name(s): 
India- Adcapone Tab, Entacom Tab, Syncapone Tab - Carbidopa + Entacapone + Levo-Dopa .
International- Comtan.
Why it is prescribed (Indications) : 
This medication is catechol-o-methyltransferase (COMT) inhibitor, used as an adjunct to levodopa/carbidopa to treat patients with idiopathic Parkinson‘s disease. It is used during the later stages when the patient does not respond well to levodopa/carbidopa. It increases the levels of levodopa/carbidopa in the brain, enhancing its effectiveness. 
When it is not to be taken (Contraindications): 
Hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
PO: The recommended dose is 200 mg with each levodopa/carbidopa up to a maximum of 1600 mg/day.
How it should be taken : 
It comes as a tablet to take by mouth.
Warnings and Precautions : 
*It may cause dizziness, lightheadedness, or fainting; do not drive a car or operate machinery, while taking this medication.
*Avoid alcohol consumption.
*It may lead to an increase in involuntary movements.
Caution needed during pregnancy and breastfeeding.
Side Effects : 
Most Common- Diarrhea, movement disorder, nausea, abdominal pain.
Skin - Sweating increased
Central Nervous System - Involuntary movements, increased or decreased movements, dizziness, anxiety, drowsiness, agitation, and worsening of condition.
ENT- Taste perversion
Gastrointestinal - Nausea, diarrhea, abdominal pain, constipation, vomiting, dry mouth, indigestion, flatulence, gastritis.
Respiratory- Difficulty in breathing.
Blood- Easy bruising
Genitourinary- Urine discoloration
Body as a whole- Back pain, fatigue, weakness
Miscellaneous- Bacterial infection.
Other Precautions : 
*Stop this medication if unwanted symptoms developed.
Storage Conditions : 
Store it at room temperature and in airtight container. Keep away from children

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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