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Enfuvirtide

Updated on : August - 2012
Latest prescription information about Enfuvirtide. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Enfuvirtide
Pronunciation : en-FUE-vir-tide
Therapeutic Classification : Antivirals
ICD Code : Y41.5
Trade Name(s): 
International- Fuzeon.
Why it is prescribed (Indications) : 
This medication is an antiretroviral agent, prescribed for HIV/AIDS. It works by decreasing the amount of HIV in the blood.
When it is not to be taken (Contraindications): 
Hypersensitivity.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
SC: Adult- The recommended dose is 90 mg (1 ml) twice daily.
How it should be taken : 
It comes as a solution for injection, to be administered by a healthcare provider subcutaneously (under the skin).
Warnings and Precautions : 
* Caution should be exercised in patients with history of blood clot or bleeding problems, smoking, lung disease, any allergy, during pregnancy and lactation.
* It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
* Do not use contaminated fluid of this medication.
* Avoid sexual contact, sharing of needles to prevent the spread of infection.
*Patient may develop Immune Reconstitution Syndrome.
Side Effects : 
Local- Pain/discomfort, in duration, redness, lesions, itching and scars.
Genitourinary- Kidney failure/inflammation.
Blood- Decrease in blood cells.
Metabolic- Increased sugar level, infections and weight loss.
Central Nervous System- Taste disturbances, paralysis and loss of reflexes, include numbness, weakness, burning pain, depression, anxiety and suicide attempt.
Heart- Heart attack.
Gastrointestinal - Constipation, abdominal pain, loss of appetite and dry mouth.
Liver- Liver inflammation/damage
Respiratory- Lung disease, respiratory distress and cough.
Other Precautions : 
* Monitor complete blood counts, liver and kidney function during the treatment.
Storage Conditions : 
Store it at room temperature (25°C), and in an airtight container.
♦ Safety Labeling Changes Approved By FDA

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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