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Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate - Indications, Dosage, Side Effects and Precautions

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Information about Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate

Generic Name : Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate
Up-to-date prescription details regarding Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate are provided here.

Pronunciation : eh-FAV-ir-enz/EM-trye-SYE-ta-been/ten-OF-oh-vir DYE-soe-PROX-il FUE-ma-rate

Learn the correct pronunciation of the Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.


ICD Code : Y41.5 Therapeutic Classification : Antiretroviral Agents

Trade Names/Brand Names of Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate

International :


Atripla

Why is Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Prescribed? (Indications)

This combination medication is used alone as a complete regimen or in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients.

When should Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate not be taken? (Contraindications)

Contraindicated in patients with known hypersensitivity; St. John's wort; Stevens-Johnson syndrome.

What is the dosage of Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate?

Adults and pediatric patients 12 years of age and older with body weight at least 40 kg (at least 88 lbs): The dose of ATRIPLA is one tablet once daily taken orally on an empty stomach. Dosing at bedtime may improve the tolerability of nervous system symptoms.
Renal Impairment: This medication is a fixed-dose combination, it should not be prescribed for patients requiring dosage adjustment such as those with moderate or severe renal impairment (creatinine clearance below 50 mL/min).

How should Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate be taken?

It comes as a tablet to take by mouth on an empty stomach. When this medication is administered with rifampin to patients weighing 50 kg or more, an additional 200 mg/day of efavirenz is recommended.

What are the warnings and precautions for Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate?

• Caution should be exercised in patients with history of high cholesterol, kidney problems, liver problems, seizures, mental illness, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• Caution should be exercised when administering nucleoside analogs, a component of atripla to any patient with known risk factors for liver disease.

• Do not use this medication with drugs containing emtricitabine or tenofovir disoproxil fumarate including Complera, Emtriva, Stribild, Truvada, or Viread, or with drugs containing lamivudine.

• This medication should not be used in children(under the age of 12), the occurrence of rash is higher than in adults.

What are the side effects of Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate?

Common - Diarrhea, nausea, fatigue, headache, depression, insomnia, abnormal dreams, dizziness, feeling weak or tired, swelling of face, lips, tongue, or throat, psychiatric symptoms and rash.
General - Lactic acidosis (increase of lactic acid in the blood, which can be fatal), muscle pain or weakness, numb or cold feeling in arms and legs, immune reconstitution syndrome.
Respiratory - Difficulty breathing, shortness of breath, rapid heart rate.
Genitourinary - Urinating less than normal or not at all.
Central Nervous System - Nervous system symptoms.
Skin - Pale skin, red skin rash, darkened skin on the palms.

What are the other precautions for Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate?

Avoid excess dosage.

What are the storage conditions for Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate?

Store at 77 degrees F (25 degrees C). Brief storage at temperature between15–30 °C (59–86 °F). Keep container tightly closed, do not use if seal over bottle opening is broken or missing.
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