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Edrophonium Injection

Latest prescription information about Edrophonium Injection. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Edrophonium Injection
Pronunciation : ED roe FOE nee um
Therapeutic Classification : Diagnostic Agents
ICD Code : Y57.6
Trade Name(s): 
International- Enlon, Tensilon, Reversol.
Why it is prescribed (Indications) : 
This medication is an acetylcholinesterase inhibitor, prescribed for diagnosis of myasthenia gravis. It prevents the breakdown of the neurotransmitter acetylcholine.
When it is not to be taken (Contraindications): 
Contraindicated in patients with intestinal, urinary obstruction; and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Adults- IV- The recommended dose is 1 mL (10 mg) and prepared with an intravenous needle, and 0.2 mL (2 mg) is injected intravenously within 15 to 30 seconds.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider into the vein.
Warnings and Precautions : 
* Caution should be exercised in patients with history of asthma, heart rhythm disorder, any allergy, and during pregnancy and breastfeeding.
Side Effects : 
Eye - Increased tears, pupillary constriction, spasm of accommodation, double visionand conjunctival hyperemia.
Central Nervous System - Convulsions, speech disorder, voice disorder and difficulty in understanding.
Respiratory - Asthma, airway obstruction and central respiratory paralysis.
Heart - Abnormal heart rhythm, low blood pressure and increased salivation.
Gastrointestinal - Gastric and intestinal secretion, nausea, vomiting, increased peristalsis, diarrhea and abdominal cramps.
Musculoskeletal - Weakness and muscle twitch.
Miscellaneous - Increased urinary frequency and incontinence, increased sweating.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at controlled room temperature (15°-30°C).

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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