Doxylamine Succinate and Pyridoxine Hydrochloride - Drug Information

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Generic Name : Doxylamine Succinate and Pyridoxine Hydrochloride

Pronunciation : dox-IL-a-meen PIR-i-DOX-een

Latest prescription information about Doxylamine Succinate and Pyridoxine Hydrochloride. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.0 | Therapeutic Classification : Antiemetics

Trade Names/Brand Names : 

International- Diclegis, Debendox, Lenotan, Merbental, Diclectin.

Why it is prescribed : 

This combination medication is used to treat nausea and vomiting or morning sickness in pregnant women who do not respond to conservative management. 

When it is not to be taken (Contraindications): 

Contraindicated in patients with known hypersensitivity, asthma, increased intraocular pressure, narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, urinary bladder-neck obstruction and women who are taking monoamine oxidase inhibitors (MAOIs).

Pregnancy Category :


A B C D X

Category A :

Well-designed and sufficient studies in pregnant women have failed to demonstrate a risk to the fetus during the first trimester of pregnancy. These drugs are considered to be safe during pregnancy.

Dosage & When it is to be taken (Indications): 

Initially, take two DICLEGIS delayed-release tablets orally at bedtime (Day 1). If this dose adequately controls symptoms the next day, continue taking two tablets daily at bedtime. However, if symptoms persist into the afternoon of Day 2, take the usual dose of two tablets at bedtime that night then take three tablets starting on Day 3 (one tablet in the morning and two tablets at bedtime). If these three tablets adequately control symptoms on Day 4, continue taking three tablets daily. Otherwise take four tablets starting on Day 4 (one tablet in the morning, one tablet mid-afternoon and two tablets at bedtime).
The maximum recommended dose is four tablets (one in the morning, one in the mid-afternoon and two at bedtime) daily.

How it should be taken : 

It comes as a tablet to take by mouth on an empty stomach.

Warnings and Precautions : 

Do not engage in activities requiring complete mental alertness such as driving or operating heavy machinery, while using this medication.
Do not use this medication if you are concurrently using central nervous system (CNS) depressants including alcohol.
Do not crush, chew, or split tablets, swallow tablets whole.
Take this medication as a daily prescription and not on an as needed basis.

Side Effects : 

  General - Drowsiness, uneasiness, chest discomfort, irritability, fatigue.
  Respiratory - Shortness of breath, fast heart rate, abnormal heart beat.
  Gastrointestinal - Abdominal pain, constipation, diarrhea, abdominal distention.
  Genitourinary - Pain during urination, urinary retention.
  Central Nervous System - Dizziness, headache, abnormal sensation such as numbness, tingling, or burning, hyperactivity.
  Psychiatric - Anxiety, insomnia, nightmares, disorientation.
  Skin - Rash, excessive sweating, itching and irritation.
  Eye - Blurred vision, visual disturbances.

Other Precautions : 

Avoid excess dosage.

Storage Conditions : 

Store between 68F to 77F (20C to 25C) in a tightly closed container away from moisture, and light. Do not remove desiccant canister from bottle.

Schedule : G

Drugs that are to be used only under medical supervision.


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