Generic Name : Doxapram Pronunciation : DOX-uh-pram Therapeutic Classification : Respiratory stimulants
India- Caropram inj, Doxapram.
International- Dopram. Why it is prescribed (Indications) :
This medication is a respiratory stimulant, prescribed for airway obstruction and drug induced respiratory depression. It alters neurotransmitters in the brain that stimulate breathing center. When it is not to be taken (Contraindications):
Contraindicated in patients with epilepsy, blood clot in lungs, stroke, heart failure, severe high blood pressure and hypersensitivity.
Dosage & When it is to be taken :
Adult: IV- Post-op resp depression- Initial: 0.5-1.5 mg/kg via injection. May repeat hourly if needed. Max total: 4 mg/kg.
Acute resp failure- 1.5-4 mg/min via infusion. How it should be taken :
It comes as a solution for injection, to be administered by a healthcare provider into the vein. Warnings and Precautions :
* Monitor blood pressure, pulse rate, kidney and liver functions regularly while taking this medication.
* Avoid rapid administration; otherwise it will lead to breakdown of blood cells.
* Patient may develop with increased risk of low blood pressure or difficulty in breathing; if so consult with your doctor.
* Caution should be exercised in patients with history of heart, liver or kidney disease, during pregnancy and breastfeeding.
Side Effects :
Central Nervous Systems- Fever, flushing, tingling, feeling warmth, burning or hot sensation, disorientation, hallucinations, headache, dizziness, hyperactivity, involuntary movements, increased deep tendon reflexes and convulsions.
Respiratory- Difficulty in breathing, increased cough, fast breath and asthma.
Heart- Inflammation of vein, irregular heart rate, chest pain, tightness in chest and high blood pressure.
Gastrointestinal- Nausea, vomiting and diarrhea.
Genitourinary- Uncontrolled urination, urinary retention and elevation of Blood Urea Nitrogen and albumin in urine.
Blood- Breakdown of blood cells, anemia and decrease in white blood cells.
Skin- Sweating and itching.
Eye- Pupil dilation.
* Patient must be provided with adequate oxygen and ventilation.
* Avoid excess/low dosage.
Storage Conditions :
Store it at room temperature (20°-25°C) and in an airtight container.
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