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Doripenem - Indications, Dosage, Side Effects and Precautions

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Information about Doripenem

Generic Name : Doripenem
Up-to-date prescription details regarding Doripenem are provided here.

Pronunciation : dor i PEN em

Learn the correct pronunciation of the Doripenem, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.


ICD Code : Y40.1 Therapeutic Classification : Antibiotics

Trade Names/Brand Names of Doripenem

India :


Icupen, Sudopen.

International :


Doribax

Why is Doripenem Prescribed? (Indications)

This medication is an antibiotic that fights bacteria. It is used to treat severe infections of the stomach (complicated intra-abdominal infections), bladder, or kidneys (pyelonephritis) and infections caused by designated susceptible bacteria.

When should Doripenem not be taken? (Contraindications)

Contraindicated in patients with known hypersensitivity, anaphylactic reactions to beta-lactams.

What is the dosage of Doripenem?

Complicated intra-abdominal infections: Adult: ≥18 yr: 500 mg every 8 hr by IV infusion over 1 hr. Treatment duration is 5-14 days; may switch to an appropriate oral therapy, after at least 3 days of parenteral therapy upon evidence of clinical improvement.
Complicated urinary tract infections: Adult: ≥18 yr: 500 mg every 8 hr by IV infusion over 1 hr. Treatment duration is 10 days, and can be extended up to 14 days for patients with concurrent bacteraemia.
Pyelonephritis: Adult: ≥18 yr: 500 mg every 8 hr by IV infusion over 1 hr. Treatment duration is 10 days, and can be extended up to 14 days for patients with concurrent bacteraemia.
Nosocomial pneumonia: Adult: ≥18 yr: 500 mg every 8 hr by IV infusion over 1 or 4 hr (Infections with less susceptible pathogens may use 4-hr infusion).

How should Doripenem be taken?

It comes as a solution for injection, administered by a healthcare provider.

What are the warnings and precautions for Doripenem?

• Caution should be exercised in patients with history of kidney impairment, seizures, pregnant and breast feeding women, children and elderly.

• May cause development of drug-resistant bacteria when used in the absence of proven or strongly suspected bacterial infection.

• Take full course of treatment as directed by your physician.

• When doripenem is inhaled, it causes pneumonitis. Hence avoid taking this medication through inhalation.

What are the side effects of Doripenem?

Central Nervous System - Headache.
Heart - Vein inflammation.
Gastrointestinal - Nausea, diarrhea.
Blood - Anemia, low number of white blood cells, decreased platelet count in blood.
Genitourinary - Kidney impairment, vaginal itching or discharge.
Skin - Itching, rash, hives, toxic epidermal necrolysis.
Infection - Oral candidiasis.
Respiratory - Difficulty in breathing.
General - Swelling of face, lips, tongue, or throat.
Lab Tests - Increased levels of hepatic enzymes.
Hypersensitivity - Stevens-Johnson Syndrome.

What are the other precautions for Doripenem?

Avoid excess dosage; prolonged use may result in Clostridium difficile-associated diarrhoea (CDAD).

What are the storage conditions for Doripenem?

Injection vials should be stored at room temperature 20 to 25°C (12 hours) or under refrigeration 3 to 5°C (72 hours) prior to reconstitution.
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