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Dofetilide

Latest prescription information about Dofetilide. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Dofetilide
Pronunciation : doe-FEH-till-ide
Therapeutic Classification : Antiarrhythmics
ICD Code : Y52.2
Trade Name(s): 
International- Tikosyn.
Why it is prescribed (Indications) : 
This medication is an antiarrhythmic agent, prescribed for irregular heart beat.  It helps the heart to beat normally.
When it is not to be taken (Contraindications): 
Contraindicated in patients with severe kidney disease, long-term QT syndrome, co-administration with other medications and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Dose is based on creatinine clearance test. The recommended dose is 125 mcg once a day to 500 mcg twice a day.
How it should be taken : 
It comes as a capsule to take by mouth, with or without food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of heart, liver or kidney disease, who are taking other medications, any allergy, during pregnancy and breastfeeding.
* It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
* Avoid alcohol consumption.
Side Effects : 
Most Frequent- Headache, chest pain, rapid heart rhythm and dizziness.
Central Nervous System- Weakness, tingling and fainting.
Gastrointestinal- Nausea, vomiting, diarrhea and abdominal pain.
Respiratory - Respiratory tract infection, difficulty in breathing and increased cough.
Musculoskeletal- Joint/muscle pain, back pain and swelling of lower limbs.
Miscellaneous- Increased sweating, severe allergic reactions, stroke and liver damage.
Other Precautions : 
* Patient may develop with increased risk of QT prolongation, if it so consult with your doctor.
Storage Conditions : 
Store it at controlled room temperature (15° to 30°C), and in an airtight container. Keep away from children.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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