Medindia

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Disulfiram - Drug Information

Generic Name : Disulfiram | Pronunciation : dye sul' fi ram
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Latest prescription information about Disulfiram. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y51.1 | Therapeutic Classification : Cholinergic Agents
Drug Information
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Trade Name(s): 

India : 



International : 

Antabuse

Why it is prescribed : 


This medication is an alcohol antagonist, prescribed for chronic alcoholism. It blocks the processing of alcohol in the body.

When it is not to be taken (Contraindications): 


Contraindicated in patients with severe heart disease, mental disorder, who are taking alcohol containing preparations and hypersensitivity.

Pregnancy Category :


A

B

C

D

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Category C :

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken (Indications): 


Adult: PO- 800 mg as a single dose on the 1st day. Reduce dose by 200 mg/day. Maintenance: 100-200 mg/day.

How it should be taken : 


It comes as a tablet to take by mouth, with or without food.

Warnings and Precautions : 

Caution should be exercised in patients with history of diabetes, thyroid disease, epilepsy, brain damage, kidney or liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause drowsiness, do not drive a car or operate machinery while taking this medication.
Avoid alcohol consumption.
Monitor liver function and complete blood cell counts regularly while taking this medication.

Side Effects : 

Eye inflammation, peripheral nerve disease, drowsiness, fatigue, impotence, headache and rash.

Other Precautions : 

Avoid excess dosage.

Storage Conditions : 

Store it at room temperature (20 to 25C) and in an airtight container. Keep away from moisture and heat.

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