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Disopyramide

Latest prescription information about Disopyramide. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Disopyramide
Pronunciation : dye soe peer' a mide
Therapeutic Classification : Antiarrhythmics
ICD Code : Y52.2
Trade Name(s): 
International- Norpace Cap, Regubeat Tab.
Why it is prescribed (Indications) : 
This medication is an antiarrhythmic, prescribed for abnormal heart rhythms. It works by making the heart more resistant to abnormal activity.
When it is not to be taken (Contraindications): 
Contraindicated in patients with cardiogenic shock, third degree AV block and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Adult: PO- 300-800 mg/day in divided doses. IV- 2 mg/kg (max: 150 mg), followed by 200 mg via oral admin after completion of injection.
How it should be taken : 
It comes as a capsule to take by mouth, with or without food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of heart disease, high blood pressure, diabetes, kidney or liver disease, increased eye pressure, myasthenia gravis, urinary retention, prostate enlargement, elderly, children, during pregnancy and breastfeeding.
* It may cause dizziness or blurred vision, do not drive a car or operate machinery while taking this medication.
* Avoid becoming overheated; otherwise heat stroke may occur.
Side Effects : 
Most Common - Dry mouth, urinary hesitancy, constipation, blurred vision and dry nose/eyes/ throat.
Genitourinary - Urinary retention and urinary frequency impotence.
Gastrointestinal - Nausea, abdominal pain, bloating/gas, loss of appetite, diarrhea and vomiting.
General - Dizziness, general fatigue/muscle weakness, headache, uneasiness and aches/pains.
Heart - Low blood pressure, heart failure, weight gain, shortness of breath, fainting and chest pain.
Skin - Generalized rash and itching.
Central nervous system - Nervousness.
Miscellaneous - Decrease in potassium level in blood and elevated cholesterol/triglycerides.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at room temperature, and in an airtight container. Keep away from children.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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