Information about Dinoprostone
Generic Name : DinoprostoneUp-to-date prescription details regarding Dinoprostone are provided here.
Pronunciation : dye noe prost' one
Learn the correct pronunciation of the Dinoprostone, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
Therapeutic Classification : Abortifacient, Cervical Ripening agents
Trade Names/Brand Names of Dinoprostone
India :
International :
Prepidil
Why is Dinoprostone Prescribed? (Indications)
This medication is a prostaglandin, prescribed for termination of pregnancy, evacuation of the uterine contents in the missed abortion, labor induction (rarely used), and dilatation of the cervix prior to labor.When should Dinoprostone not be taken? (Contraindications)
It is contraindicated in patients allergic to prostaglandins, patients with heart, lung, kidney, liver disease or pelvic inflammatory disease.What is the dosage of Dinoprostone?
Vaginal Dilatation of cervix, induction and augmentation of labor- As gel: 0.5mg, may repeat 6 hr later if needed up to a maximum of 1.5 mg/24 hour.Labor induction- As gel: 1 mg, then 1 or 2 mg 6 hr later if neededup to a maximum of 3 mg. As pessary: 3 mg, then 3 mg 6-8 hour later if neededup to a maximum of 6 mg. Suppository: 20mg, inserted into vagina.
Pregnancy termination: It is injected outside the amniotic sac As 100 mcg/ml solution, 1 ml, followed by 1-2 ml at 2-hr intervals according to response.
How should Dinoprostone be taken?
It comes as a vaginal suppository and as a gel that is inserted into the vagina and solution for injection administered by a health professional. Patient should lie down after insertion of this medication.What are the warnings and precautions for Dinoprostone?
•It may raise eye pressure hence should be used with caution in patients with glaucoma.Caution needed for patients with history of previous cesarean section, asthma; anemia; uterine surgery; diabetes; high or low blood pressure; placenta previa(condition where the placenta partly or completely covers the outlet of the uterus); a seizure disorder; previous multiple pregnancies; glaucoma or increased pressure in the eye; cephalopelvic disproportion (babies head or body is too large to fit through the mother's pelvis); previous difficult or traumatic deliveries; or unexplained vaginal bleeding.
What are the side effects of Dinoprostone?
Genitourinary- Increased uterine contraction with or without fetal distress, rupture of the uterusGastrointestinal - Nausea, vomiting, diarrhea, and abdominal pain.
Miscellaneous- Fever, low blood pressure, increase in eye pressure, headache, breathing difficulty.
Blood- An increased risk of postpartum disseminated intravascular coagulation.
What are the other precautions for Dinoprostone?
Do not change your dose unless your doctor tells you to do so.What are the storage conditions for Dinoprostone?
Cervical gel: Refrigerate at 2-8°C. Vaginal supp: Store in a freezer below -20°C. Vaginal insert: Store in a freezer between -20°C & -10°C.Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.
