Trade Names/Brand Names :
- DES, stilphostrol.
Why it is prescribed :
This medication is a synthetic nonsteroidal estrogen, prescribed for the prevention of miscarriage, breast cancer, premature birth and prostate enlargement.
When it is not to be taken (Contraindications):
Contraindicated in patients with breast cancer, blood clots, and during pregnancy.
Category X :
Animal and/or human studies have demonstrated fetal injury and potential risks outweigh the benefits of the drug in pregnancy. These drugs are found to be harmful when taken during pregnancy, and should not be used.
Dosage & When it is to be taken (Indications):
Dosage is based on patient’s condition.
Adult: PO- The recommended dose is 10-20 mg/day.
As Vaginal pessary: 1 mg/day.
How it should be taken :
It comes as a tablet to take by mouth, with or without food.
It also comes as a pessary to insert into the vagina.
Warnings and Precautions :
• Caution should be exercised in patients with history of breast lumps and cancer, high blood pressure, diabetes, asthma, epilepsy, migraine headaches, liver, heart or kidney disease, mental depression, high blood pressure during pregnancy and breastfeeding women.
Side Effects :
• Most frequent
Abdominal pain with cramps, abdominal swelling, loss of appetite, decreased breast milk flow, painful menstruation, breast enlargement in males, nausea, swelling in the leg, vaginal infection and weight gain.
Other Precautions :
Avoid excess dosage.
Storage Conditions :
Store it at room temperature, and in an airtight container. Keep away from children.