Generic Name : Dextromethorphan and Quinidine Pronunciation : dex-troe-meth-OR-fan- KWIN-i-deen
International- Nuedexta. Why it is prescribed (Indications) :
This combination medication contains CYP2D6 inhibitor and a sigma-1 receptor agonist, prescribed for pseudobulbar affect (PBA). It is the first drug approved by FDA for the treatment of pseudobulbar affect (PBA). When it is not to be taken (Contraindications): Contraindicated in patients with a prolonged QT interval, congenital long QT syndrome, who are taking monoamine oxidase inhibitors (MAOIs), and hypersensitivity.
Dosage & When it is to be taken :
The recommended starting dose is one capsule daily by mouth for first 7 days, then 2 capsules per day. How it should be taken :
It comes as a capsule to take by mouth, as directed by your physician. Warnings and Precautions :
* Caution should be exercised in patients with history of heart, liver or kidney disease, high or low blood pressure, decrease in platelets, stroke, Alzheimer’s disease, low blood electrolyte levels, slow heartbeat, trouble in walking, myasthenia gravis, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.
* It may cause dizziness, drowsiness, or blurred vision, do not drive a car or operate machinery and get up slowly from bed while taking this medication.
* It may reduce platelet counts; avoid injury or bruising. Side Effects :
Most Common - Muscle spasticity, respiratory failure, abdominal pain, weakness, dizziness, fall, and muscle spasms.
Miscellaneous - Diarrhea, dizziness, cough, vomiting, swelling in the extremities, urinary tract infection, flatulence.
* Avoid excess dosage. Storage Conditions :
Store it at controlled room temperature (25°C).
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