Desipramine - Drug Information

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General Information on Desipramine

Generic Name : Desipramine

Pronunciation : dess ip'ra meen

Latest prescription information about Desipramine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y49.0 | Therapeutic Classification : Psychotherapeutics

Trade Names/Brand Names of Desipramine

International- Norpramin.

Why is Desipramine Prescribed? (Indications)

This medication is an antidepressant, prescribed for depression. It elevates mood by raising the level of neurotransmitters in nerves of the brain.

When should Desipramine not to be taken? (Contraindications)

Contraindicated in patients with heart attack, co-administration with MAOI’s or within 14 days of treatment with MAOI’s and hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Desipramine?

PO- The usual adult dose is 100 to 200 mg per day.

How should Desipramine be taken?

It comes as a capsule and tablet to take by mouth, with or without food.

What are the warnings and precautions for Desipramine?

• Caution should be exercised in patients with increased eye pressure, enlarged prostate, kidney or liver disease, urinary obstruction, mental disorders, seizures, suicidal thoughts, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
• It may cause drowsiness, dizziness, blurred vision or lightheadedness, do not drive a car or operate machinery and get slowly from bed while taking this medication.
• Avoid alcohol consumption.
• It may affect blood sugar, monitor sugar level regularly while taking this medication.
• Avoid exposure to sunlight; otherwise it may cause sunburn.
• Patient may develop with increased risk of Serotonin Syndrome with the following symptoms: restlessness, diarrhea, fast heart beat, incoordination, nausea, vomiting. If it is so consult with your healthcare provider.

What are the side effects of Desipramine?

•  Heart: Low/high blood pressure, palpitations, heart block, heart attack, stroke, abnormal heart rhythm, fast heart rate and sudden death.
•  Psychiatric: Confusion, hallucinations, disorientation, delusions, anxiety, restlessness, agitation, sleeplessness and abnormal dreams.
•  Central Nervous System: Numbness, tingling, incoordination, tremors, nerve disease, seizures and alterations in EEG patterns.
•  Eye and ENT: Dry mouth, blurred vision, visual disturbances, dilatation of pupil and increased eye pressure.
•  Allergic: Skin rash, hives, itching, photosensitivity, swelling in the face and tongue or general and fever.
•  Blood: Bone marrow depression.
•  Gastrointestinal: Loss of appetite, nausea, vomiting, peculiar taste, abdominal cramps, diarrhea, mouth ulcer, black tongue, jaundice, liver inflammation, constipation, intestinal obstruction.
•  Genitourinary: Breast enlargement in male, milk secretion in the female, increased or decreased sexual drive, impotence, painful ejaculation, testicular swelling, urinary retention, delayed urination and dilation of urinary tract.
•  Miscellaneous : Weight gain or loss, flushing, urinary frequency, drowsiness, dizziness, weakness, fatigue, headache, fever and hair loss.

What are the other precautions for Desipramine?

Patient may develop with increased risk of neuroleptic malignant syndrome (NMS) with the following symptoms: confusion, abnormal thinking, fast or irregular heartbeat, sweating, fever and muscle stiffness. If it is so consult with your doctor.
Avoid becoming overheated; otherwise heat stroke may occur.

What are the storage conditions of Desipramine?

Store it at room temperature (30°C) and in an airtight container.

♦ Safety Labeling Changes Approved By FDA

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