Generic Name : Desipramine Pronunciation : dess ip'ra meen Therapeutic Classification : Psychotherapeutics ICD Code : Y49.0♦ Safety Labeling Changes Approved By FDA
International- Norpramin. Why it is prescribed (Indications) :
This medication is an antidepressant, prescribed for depression. It elevates mood by raising the level of neurotransmitters in nerves of the brain. When it is not to be taken (Contraindications):
Contraindicated in patients with heart attack, co-administration with MAOI’s or within 14 days of treatment with MAOI’s and hypersensitivity.
Dosage & When it is to be taken :
PO- The usual adult dose is 100 to 200 mg per day. How it should be taken :
It comes as a capsule and tablet to take by mouth, with or without food. Warnings and Precautions :
* Caution should be exercised in patients with increased eye pressure, enlarged prostate, kidney or liver disease, urinary obstruction, mental disorders, seizures, suicidal thoughts, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
* It may cause drowsiness, dizziness, blurred vision or lightheadedness, do not drive a car or operate machinery and get slowly from bed while taking this medication.
* Avoid alcohol consumption.
* It may affect blood sugar, monitor sugar level regularly while taking this medication.
* Avoid exposure to sunlight; otherwise it may cause sunburn.
*♦ Patient may develop with increased risk of Serotonin Syndrome with the following symptoms: restlessness, diarrhea, fast heart beat, incoordination, nausea, vomiting. If it is so consult with your healthcare provider. Side Effects :
Heart- Low/high blood pressure, palpitations, heart block, heart attack, stroke, abnormal heart rhythm, fast heart rate and sudden death.
Psychiatric- Confusion, hallucinations, disorientation, delusions, anxiety, restlessness, agitation, sleeplessness and abnormal dreams.
Central Nervous System- Numbness, tingling, incoordination, tremors, nerve disease, seizures and alterations in EEG patterns.
Eye and ENT- Dry mouth, blurred vision, visual disturbances, dilatation of pupil and increased eye pressure.
Allergic- Skin rash, hives, itching, photosensitivity, swelling in the face and tongue or general and fever.
Blood- Bone marrow depression.
Gastrointestinal- Loss of appetite, nausea, vomiting, peculiar taste, abdominal cramps, diarrhea, mouth ulcer, black tongue, jaundice, liver inflammation, constipation, intestinal obstruction.
Genitourinary- Breast enlargement in male, milk secretion in the female, increased or decreased sexual drive, impotence, painful ejaculation, testicular swelling, urinary retention, delayed urination and dilation of urinary tract.
Miscellaneous - Weight gain or loss, flushing, urinary frequency, drowsiness, dizziness, weakness, fatigue, headache, fever and hair loss.
* Patient may develop with increased risk of neuroleptic malignant syndrome (NMS) with the following symptoms: confusion, abnormal thinking, fast or irregular heartbeat, sweating, fever and muscle stiffness. If it is so consult with your doctor.
* Avoid becoming overheated; otherwise heat stroke may occur. Storage Conditions :
Store it at room temperature (30°C) and in an airtight container.
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