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Denosumab

Latest prescription information about Denosumab. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Denosumab
Pronunciation : den-OH-sue-mab
Trade Name(s): 
International- Prolia.
Why it is prescribed (Indications) : 
This medication is a human monoclonal antibody, prescribed for osteoporosis, treatment induced bone loss, bone metastases, rheumatoid arthritis, multiple myeloma and giant cell tumor of bone.

When it is not to be taken (Contraindications): 


Contraindicated in patients with multiple myeloma, and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


When it is to be taken : 
SC- The recommended dose is 120 mg, for every 4 weeks in the upper arm, upper thigh, or abdomen.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider under the skin.
Special Instruction : 
* Caution should be exercised in patients with history of kidney impairment, anemia, low blood calcium, any allergy, who are taking other medications, thyroid or kidney disease, infection, during pregnancy and breastfeeding.
* In some patients, this medication may cause jawbone problems.
Side Effects : 
Most Common - Fatigue/weakness, decreased level of phosphate in blood, nausea, diarrhea, headache and cough.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at room temperature (25°C).

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