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Denosumab - Indications, Dosage, Side Effects and Precautions

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Information about Denosumab

Generic Name : Denosumab
Up-to-date prescription details regarding Denosumab are provided here.

Pronunciation : den-OH-sue-mab

Learn the correct pronunciation of the Denosumab, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.


ICD Code : Y43.4 Therapeutic Classification : Monoclonal antibodies

Trade Names/Brand Names of Denosumab

International :


Prolia

Why is Denosumab Prescribed? (Indications)

This medication is a human monoclonal antibody, prescribed for osteoporosis, treatment induced bone loss, bone metastases, rheumatoid arthritis, multiple myeloma and giant cell tumor of bone.

When should Denosumab not be taken? (Contraindications)

Contraindicated in patients with hypocalcemia, multiple myeloma, hypersensitivity and during pregnancy.

What is the dosage of Denosumab?

SC- The recommended dose is 120 mg, for every 4 weeks in the upper arm, upper thigh, or abdomen.

How should Denosumab be taken?

It comes as a solution for injection to be administered by a healthcare provider under the skin.

What are the warnings and precautions for Denosumab?

• Caution should be exercised in patients with history of kidney impairment, anemia, low blood calcium, any allergy, who are taking other medications, thyroid or kidney disease, infection, during pregnancy and breastfeeding.

• In some patients, this medication may cause jawbone problems.

Patient may develop Osteonecrosis of the Jaw (ONJ) with the following symptom: gum lesions. If it is so consult with your healthcare provider immediately.

What are the side effects of Denosumab?

Most Common - Fatigue/weakness, decreased level of phosphate and calcium in blood, nausea, diarrhea, headache and cough.

What are the other precautions for Denosumab?

Avoid excess dosage.

What are the storage conditions for Denosumab?

Store it at room temperature (25°C).
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