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Defibrotide Injection - Indications, Dosage, Side Effects and Precautions

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Information about Defibrotide Injection

Generic Name : Defibrotide Injection
Up-to-date prescription details regarding Defibrotide Injection are provided here.

Understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.


Trade Names/Brand Names of Defibrotide Injection

India :


Defitelio

Why is Defibrotide Injection Prescribed? (Indications)

Defibrotide injection is an antithrombotic agent that is used for the treatment of hepatic veno occlusive disease (VOD) where the blood vessels inside the liver is blocked. This condition is also known as the Sinusoidal Obstruction Syndrome. The drug is used specifically in those patients who have kidney or lung problems following a hematopoietic stem cell transplantation (HSCT).

Defibrotide injection mainly acts by preventing the formation of blood clots.

When should Defibrotide Injection not be taken? (Contraindications)

Defibrotide injection is contraindicated in patients who are allergic to the drug, with history of bleeding problems, with the use of any other prescription medicines or nutritional supplements which could also cause bleeding like fibrinolytics and anticoagulants, during pregnancy and breast-feeding.

What is the dosage of Defibrotide Injection?

The recommended dose of defibrotide injection is 6.25mg/kg to be given intravenously over 2 hours for every 6 hours. The treatment is followed for a minimum of 21 days.

How should Defibrotide Injection be taken?

Defibrotide injection is administered in the form of an intravenous infusion into the vein.

What are the warnings and precautions for Defibrotide Injection?

• Defibrotide injection should be stopped immediately if there is any sign of bleeding as the drug may further increase the bleeding risk.

• The patient should be monitored regularly for any allergic reactions and should not be administered if it is found to cause serious reactions.

What are the side effects of Defibrotide Injection?

General: Fever, allergic reaction, low blood pressure.
Bleeding: Bleeding could result in symptoms like bruising of the skin, nose bleeding, or blood in the stool or urine. Bleeding in the brain can cause headache, vision problems, confusion and slurred speech.
Gastrointestinal: Nausea, vomiting, diarrhea.
Skin: Itching, skin rashes
Respiratory: Cough, pneumonia
Central Nervous System: Dizziness, light headedness.

What are the other precautions for Defibrotide Injection?

• Breast-feeding is not recommended while taking defibrotide injection as it has the possibility of causing serious side effects to the baby.

• The health care provider should not use the injection if there are visible particles or discoloration.

What are the Drug Interactions of Defibrotide Injection?

Defibrotide injection should be avoided with:

• Anticoagulant medicines (Blood - thinners) – e.g. Apixaban, dabigatran, enoxaparin, rivaroxaban, warfarin.
• Tissue Plasminogen Activators – e.g. Alteplase, reteplase, tenecteplase.

Concomitant administration of defibrotide injection with these drugs might increase the risk of bleeding.

What are the storage conditions for Defibrotide Injection?

Store the injection at room temperature preferably between (20-25°C).
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