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Daptomycin

Updated on : May - 2012
Latest prescription information about Daptomycin. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Daptomycin
Pronunciation : DAP-toe-MYE-sin
Therapeutic Classification : Antibiotics
ICD Code : Y40.9
Trade Name(s): 
International- Cubicin.
Why it is prescribed (Indications) : 
This medication is an antibiotic, prescribed for serious infections. It works by killing the bacteria.
When it is not to be taken (Contraindications): Hypersensitivity.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
Adult- IV- The recommended dose is 4 mg/kg in 0.9% sodium chloride injection once every 24 hours for 7 to 14 days.
How it should be taken : 
It comes as a powder for injection (diluted with fluid), to be administered by a healthcare provider.
Warnings and Precautions : 
* Caution should be exercised in patients with history of muscle, nerve problems, liver, or kidney disease, bowel problems caused by antibiotic use, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Side Effects : 
Gastrointestinal - Diarrhea.
Central Nervous system- Headache and dizziness.
Skin - Rash.
Gastrointestinal - Abnormal liver function tests.
Genitourinary - Urinary tract infections.
Heart - Low blood pressure.
Respiratory - Difficulty in breathing and Eosinophilic pneumonia.

Body as a Whole - Fatigue, weakness, rigors, flushing and hypersensitivity
Other Precautions : 
* Avoid excess and long-term use of this medication.
Storage Conditions : 
Store it in refrigerator (2 to 8°C).

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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