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Dantrolene

Updated on : July - 2012
Latest prescription information about Dantrolene. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Dantrolene
Pronunciation : dan' troe leen
Therapeutic Classification : Skeletal Muscle Relaxants
ICD Code : Y55.1
Trade Name(s): 
International- Dantrium.
Why it is prescribed (Indications) : 
This medication is a muscle relaxant, prescribed for certain types of spasticity or muscle spasms. It works by relaxing the muscles.
When it is not to be taken (Contraindications): 
Contraindicated in patients with severe liver impairment.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Adult- Po- The recommended dose range is 25-100mg, orally in divided doses.
How it should be taken : 
It comes as a capsule to take by mouth, with or without food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of heart, lungs or liver problems, any allergy, who are taking other medications, elderlyduring pregnancy and breastfeeding.
* It may cause dizziness, drowsiness or lightheadedness, do not drive a car or operate machinery while taking this medication.
* Avoid alcohol consumption.
Side Effects : 
Gastrointestinal - Constipation, GI bleeding, loss of appetite, difficulty in swallowing, gastric irritation, abdominal cramps, nausea and vomiting.
Liver - Liver inflammation.
Central Nervous System - Speech disturbances, seizures, headache, lightheadedness, visual disturbances, double vision, alteration of taste and sleeplessness.
Heart - Fast heart rate, erratic blood pressure and vein inflammation, heart failure .
Psychiatric - Mental depression, mental confusion and nervousness.
Genitourinary - Increased urinary frequency, blood in urine, difficult erection, urinary incontinence, difficult urination and/or urinary retention.
Skin - Abnormal hair growth, acne-like rash, itching, hives, eruption and increased sweating.
Musculoskeletal - Muscle pain and backache.
Respiratory - Feeling of suffocation and respiratory depression.
Eye and ENT - Excessive tearing.
Hypersensitivity - Lung infection.
Blood- Anemia, leukopenia, lymphocytic lymphoma, thrombocytopenia.
Miscellaneous - Chills and fever.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Keep this medication in the container it came in, tightly closed and out of the reach of children. Store it at room temperature.
♦ Safety Labeling Changes Approved By FDA

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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