Why it is prescribed :
This medication is an anticoagulant (blood thinner) that prevents blood clots in persons undergoing surgery. Along with aspirin this medication is prescribed for heart attack, unstable angina (chest pain). It is also used to reduce the recurrence of blood clots in certain cancer patients and during dialysis.
When it is not to be taken (Contraindications):
Hypersensitivity, active major bleeding, severe coagulation disorders; lumbar puncture; sympathetic block; brain, spinal cord, eye or ear surgery; severe hypertension.
Category B :
Animal studies have failed to demonstrate a risk to the fetus and appropriate studies on pregnant women are lacking.
Dosage & When it is to be taken (Indications):
Subcutaneous- Unstable angina, Heart Attack-
Adult: 120 IU/kg every 12 hour continued for 5-8 days with concomitant low-dose of aspirin. Max: 10,000 IU every 12 hours.
The recommended dose is 2500 IU to 5000 IU once daily for prophylaxis; 100uU/kg 12 hourly or 200 U/kg 24 hourly for treatment of DVT.
Extended Treatment of Symptomatic Venous Thromboembolism in Cancer Patients-
Adults:Subcutaneous For the first 30 days of treatment, give 200 IU/kg once daily (max, 18,000 units/day). Months 2 to 6: Administer 150 IU/kg once daily (max, 18,000 IU/day).
Prophylaxis of clotting in extracorporeal circulation in haemodialysis or haemofiltration
-Adult: 30-40 units/kg via IV injection, followed by an IV infusion of 10-15 units/kg/hour. A single dose of 5000 units may be given for haemodialysis or haemofiltration session lasting <4 hour. For patients at high risk of bleeding complications or who are in acute kidney failure: 5-10 units/kg via IV injection followed by an infusion of 4-5 units/kg/hour.
How it should be taken :
It comes as a solution for injection, to be injected under the skin (Subcutaneously) by a healthcare provider.
Warnings and Precautions :
Monitor coagulation time.
Caution needed for patients with history especially of: bleeding disorders, ulcers, liver disease, kidney disease, high blood pressure, heart disease, strokes, allergies (especially to heparin or pork). This medication should be used only if clearly needed during pregnancy or while breast-feeding.
Side Effects :
Hair loss, skin necrosis.
Blood in urine.
Any bleeding event, blood clot in the spine.
Allergic reactions, including itching, rash, fever, injection-site reaction, hypersensitivity reactions.
Injection-site blood clot, wound hematoma, injection-site pain.
Other Precautions :
Do not administer by IM injection.
Storage Conditions :
Injection: Store below 25°C. Store it in airtight container and keep away from children.