This medication is a cytotoxic chemotherapy, prescribed for Wilm's tumor, Ewing’s sarcoma and testicular cancer. This medication slows the growth and spread of cancer cells in the body.
It should not be given in patients with chickenpox or herpes zoster, and hypersensitivity.
Adult: IV- Wilm's tumor; Ewing's sarcoma; Childhood rhabdomyosarcoma- 15 mcg/kg/day for 5 days in combination regimens.
Gestational trophoblastic tumours- 12 mcg/kg/day for 5 days as a single agent.
Metastatic nonseminomatous testicular cancer- 1 mg/m2 on day 1 of combination regimens.
It comes as a solution for injection to be administered by a healthcare provider into the vein.
• Caution should be exercised in patients with history of bone marrow problems, obesity, radiation therapy, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
• It may cause nausea, vomiting or loss of appetite, if it so consult with your doctor.
• This medication may reduce platelet counts, avoid injury or bruising.
• Miscellaneous :
Uneasiness, fatigue, lethargy, fever, muscle pain, inflammation of the rectum, decreased calcium level in blood, growth retardation and infection.
• Lung : Lung inflammation.
• Gastrointestinal : Loss of appetite, indigestion, nausea, vomiting, abdominal pain, diarrhea, gastrointestinal ulceration, mouth ulcer and inflammation of esophagus.
• Liver : Liver toxicity.
• Blood : Anemia and decrease in blood counts.
• Skin : Hair loss, skin eruptions, pimples and redness.
Avoid vaccination during therapy.
Monitor liver function, kidney function and blood counts regularly while taking this medication.
Intravenous: Store it at room temperature (25°C).
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