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Dacarbazine

Latest prescription information about Dacarbazine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Dacarbazine
Pronunciation : da kar' ba zeen
Therapeutic Classification : Chemotherapy
Trade Name(s): 
India- Arzi Vial, Celdaz Inj, Dabaz Vial , Dacarba Vial , Dacarex Vial , Dacarin Vial, Dacarzine Vial, Daczin Vial, Decarb Vial, and Oncodac Vial.
International- DTIC-Dome.
Why it is prescribed (Indications) : 
This medication is an antineoplastic chemotherapy drug, prescribed for melanoma and Hodgkin's disease. This medication slows the growth and spread of cancer cells in the body.  
When it is not to be taken (Contraindications): 
Contraindicated in patients with bone marrow suppression and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Malignant Melanoma: The recommended dosage is 2 to 4.5mg/kg/day for 10 days. Treatment may be repeated at 4-week intervals.
Hodgkin's Disease: The recommended dose is 150mg/square meter body surface/day for 5 days.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider into the vein.
Warnings and Precautions : 
* Caution should be exercised in patients with history of liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* Avoid drinking alcoholic beverages and citrus fruit juices.
Side Effects : 
Most Common - Nausea, vomiting, diarrhea and loss of appetite.
Miscellaneous - Hair loss, tingling, photosensitivity, rashes and facial flushing.
Liver - Liver damage.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it in refrigerator (2-8°C). Do not freeze it.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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