Generic Name : Cyclophosphamide Pronunciation : sye kloe foss' fa mide
Therapeutic Classification : Chemotherapy Trade Name(s):
India- Cyclophosphamide Vial, Cycloxan Inj, Cycloxan Tab, Cycrame Vial, Cydoxan Vial, Cyphos Vial, Eldamide Inj, Eldamide Tab, Endoxan Tab, Endoxan-Asta Tab, Endoxan-Asta Vial, Ledoxan Inj, Ledoxan Tab, Neophos Vial, Oncomide Tab, Oncomide Vial, Oncophos Vial, Oncoxan Vial, Shanmyde Vial, Uniphos Tab, Uniphos Vial.
International- Cytoxan, Neosar. Why it is prescribed (Indications) :
This medication is an antineoplastic agent, prescribed for many types of cancers like lymphatic cancer, cancer of white blood cells and plasma cells, etc,. It slows or stops the growth of cancer cells in your body. When it is not to be taken (Contraindications):
It may cause bladder bleeding in patients with bone-marrow defect, acute infection, and drug- or radiation-induced urinary tract toxicity, harmful to pregnancy and lactation.
Dosage & When it is to be taken :
Adults and Children- Treatment of Malignant Diseases- The recommended dose is 40 to 50 mg/kg given intravenously in divided doses over a period of 2 to 5 days.
Treatment of Nonmalignant Diseases- An oral dose of 2.5 to 3 mg/kg daily for a period of 60 to 90 days is recommended. How it should be taken :
It comes as a tablet to take by mouth, on an empty stomach.
It also comes as a solution for injection to be administered by a healthcare provider into the vein. Warnings and Precautions :
*It may cause blood disorders.
*Caution should be exercised in elderly or debilitated, diabetic patients, who have undergone adrenal removal operation.
*Monitor blood profile and presence of RBCs in urine regularly.
*Maintain adequate hydration and frequent urination to reduce the risk of cystitis. Side Effects :
Heart- Acute cardiac toxicity, heart failure, blood in the pericardium, fluid accumulation, irreversible destruction of heart muscle, inflammation of pericardium.
Central Nervous System- Lack of energy, general discomfort.
Skin- Hair loss, nail changes, skin pigmentation, skin rash, toxic epidermal blistering.
Gastrointestinal- Abdominal discomfort and pain, loss of appetite, diarrhea, bleeding in colon, sore throat, nausea, vomiting.
Hormone- Syndrome of inappropriate anti- diuretic hormone hyper secretion.
Genitourinary- Absence of a menstrual period associated with decreased estrogen and increased gonadotropin secretion, atypical urinary bladder epithelial cells in the urine, absence of sperm, urinary bladder inflammation, blood in urine, impairment of fertility, cyst in ovary, death of tubular cells , urinary bladder cyst.
Blood-Lymphatic- Decrease in all types of blood cells with fever.
Hypersensitivity- Systemic vasodilatation which results in low blood pressure, including death.
Respiratory- Scarring of both lungs, scarring and thickening of the lung tissues.
Miscellaneous- Infections, cancers caused by treatment with radiation or chemotherapy.
*It may cause absence of menstrual period in women. Storage Conditions :
Store at 25ï¿½C. Store it in air tight container and keep away from children.
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