Co-trimoxazole - Drug InformationGeneric Name : Co-trimoxazole | Pronunciation : coe try mox' a zole
International :Bactrim, Bactrim DS, Septra, Septra DS, Sulfatrim
Why it is prescribed (Indications) :
This medication is a combination of trimethoprim and sulfamethoxazole, prescribed for certain types bacterial infections. It is also used to treat traveler’s diarrhea. It eliminates bacteria that cause various infections.
When it is not to be taken (Contraindications):
Contraindicated in patients with anemia, hypersensitivity, during pregnancy and breast-feeding.
Pregnancy Category :
Category C :Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Dosage & When it is to be taken :
It is a fixed combination product containing sulfamethoxazole and trimethoprim in 5:1 ratio.
Adult- PO- The recommended dose is 2 tablets every 12 hours for a period of 10 to 14 days.
Child- The recommended dose is 8 mg/kg of trimethoprim and 40 mg/kg of sulfamethoxazole daily in 2 divided doses every 12 hours.
How it should be taken :
It comes as a tablet and liquid to take by mouth, with or without food.
Warnings and Precautions :Caution should be exercised in patients with history of liver or kidney disease, asthma, severe allergies, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency (an inherited blood disease), any allergy, who are taking other medications.
Avoid exposure to sunlight.
Side Effects :
Most Common - Nausea, vomiting and loss of appetite.
Blood - Decrease in blood cell counts.
Allergic - Skin inflammation, eruptions, rash, itching, redness, hives, bruising and photosensitivity.
Gastrointestinal - Liver inflammation/damage, jaundice, hepatic necrosis, elevation in liver enzymes, inflammation of intestine/pancreas/tongue, mouth ulcer, abdominal pain and diarrhea.
Genitourinary - Kidney failure, Blood Urea Nitrogen and absence of urination.
Central Nervous System - Brain inflammation, convulsions, incoordination, fainting, ringing in the ear, headache, hallucinations, depression and nervousness.
Metabolic - Low blood sugar.
Musculoskeletal - Joint/muscle pain.
Respiratory - Cough, shortness of breath and lung infection.
Miscellaneous - Weakness, fatigue and sleeplessness.