Generic Name : Colistimethate Injection Pronunciation : koe lis ti meth' ate Therapeutic Classification : Antibacterials and Antibiotics ICD Code : Y40
India- Alnamycin Syr, Colgit Syr, Coligyl Dry Syr, Colistop Ds Dry Syr, Gdsafe Syr , Gdsafe-Ds Dry Syr, Harmless Susp, Walamycin Syr.
International- Coly-Mycin M. Why it is prescribed (Indications) :
This medication is a polymyxin antibiotic, prescribed for infections caused by bacteria. The antibiotic fights against the bacteria in the body. When it is not to be taken (Contraindications):
Dosage & When it is to be taken :
PO- GI infections; Bowel sterilization- 1.5-3 million units 3 times/day.
IV/IM- GI infections; Bowel sterilization as colistimethate Na: 6 million units/day in 3 divided doses. Max: 6-million units/24 hour.
Inhalation- Adjunct to antimicrobial therapy in respiratory infections as colistimethate Na: 1-2 million units twice daily. Max: 2 million units 3 times/day for up to 3 month in frequent recurrent infections. How it should be taken :
It comes as a syrup to take by mouth. Warnings and Precautions :
* Caution should be exercised in patients with history of preexisting kidney impairment, disorders of neuromuscular transmission, during pregnancy and lactation.
* Monitor liver enzyme level and Blood Urea Nitrogen level regularly while on treatment. Side Effects :
Gastrointestinal- Gastrointestinal upset.
Central Nervous System- Tingling of extremities and tongue, slurred speech, dizziness and fainting.
Skin - Generalized itching, hives and rash.
Body as a Whole - Fever.
Respiratory - Respiratory disorder and shortness of breath.
Genitourinary - Kidney damage and decreased urine output.
*Avoid excess dosage and alcohol consumption. Storage Conditions :
Store reconstituted solution in refrigerator at 2°-8°C (36°-46°F) or between 20°-25°C
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