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Colistimethate Injection

Latest prescription information about Colistimethate Injection. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Colistimethate Injection
Pronunciation : koe lis ti meth' ate
Therapeutic Classification : Antibacterials and Antibiotics
ICD Code : Y40
Trade Name(s): 
India- Alnamycin Syr, Colgit Syr, Coligyl Dry Syr, Colistop Ds Dry Syr, Gdsafe Syr , Gdsafe-Ds Dry Syr, Harmless Susp, Walamycin Syr.
International- Coly-Mycin M.
Why it is prescribed (Indications) : 
This medication is a polymyxin antibiotic, prescribed for infections caused by bacteria. The antibiotic fights against the bacteria in the body.  
When it is not to be taken (Contraindications): 
Hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
PO- GI infections; Bowel sterilization- 1.5-3 million units 3 times/day.
IV/IM- GI infections; Bowel sterilization as colistimethate Na: 6 million units/day in 3 divided doses. Max: 6-million units/24 hour.
Inhalation- Adjunct to antimicrobial therapy in respiratory infections as colistimethate Na: 1-2 million units twice daily. Max: 2 million units 3 times/day for up to 3 month in frequent recurrent infections.
How it should be taken : 
It comes as a syrup to take by mouth.
Warnings and Precautions : 
* Caution should be exercised in patients with history of preexisting kidney impairment, disorders of neuromuscular transmission, during pregnancy and lactation.
* Monitor liver enzyme level and Blood Urea Nitrogen level regularly while on treatment.
Side Effects : 
Gastrointestinal- Gastrointestinal upset.
Central Nervous System- Tingling of extremities and tongue, slurred speech, dizziness and fainting.
Skin - Generalized itching, hives and rash.
Body as a Whole - Fever.
Respiratory - Respiratory disorder and shortness of breath.
Genitourinary - Kidney damage and decreased urine output.
Other Precautions : 
*Avoid excess dosage and alcohol consumption.
Storage Conditions : 
Store reconstituted solution in refrigerator at 2°-8°C (36°-46°F) or between 20°-25°C

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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