Clozapine - Drug Information

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General Information on Clozapine

Generic Name : Clozapine

Pronunciation : kloe' za peen

Latest prescription information about Clozapine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y49.5 | Therapeutic Classification : Psychotherapeutics

Why is Clozapine Prescribed? (Indications)

This medication is an antipsychotic, prescribed for schizophrenia.  It changes the activity of certain natural substances in the brain.

When should Clozapine not to be taken? (Contraindications)

Contraindicated in patients with myeloproliferative disorders (abnormal growth of blood cells), uncontrolled epilepsy, intestinal obstruction, drug-induced agranulocytosis, co-adminisered with drugs that are causing agranulocytosis and hypersensitivity.

Pregnancy Category

A B C D X

Category B :

Animal studies have failed to demonstrate a risk to the fetus and appropriate studies on pregnant women are lacking.

What is the dosage of Clozapine?

The initial dose is 12.5 mg two times/day, and the dose is increased by 25–50 mg each day, until the dose reaches 300–450 mg per day.
The usual dosage range is 300–600 mg per day. Maximum: 900mg/day.

How should Clozapine be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Clozapine?

• Caution should be exercised in patients with history of intestinal obstruction, increased eye pressure, irregular heartbeat, QT prolongation, heart arrest, enlarged prostate, high or low blood pressure, heart, kidney, lung or liver disease, any allergy, who are taking this medications, during pregnancy and breast feeding.
• Avoid alcohol consumption.
• It may cause drowsiness, dizziness or lightheadedness, do not drive a car or operate machinery and get up slowly from bed while taking this medication.
• Patient may develop with increased risk of agranulocytosis, high blood pressure, diabetes, monitor blood counts, blood pressure and sugar level regularly while taking this medication.
• It may cause neuroleptic malignant syndrome (NMS) with the following symptoms: fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. If it so consult with your doctor.

What are the side effects of Clozapine?

•   Central Nervous System: Drowsiness, seizures, dizziness and fainting.
•   Heart : Fast heart rate, low blood pressure, heart arrest, and ECG changes.
•   Gastrointestinal : Nausea and vomiting.
•   Blood : Decrease in blood cell counts and fever.
•   Central Nervous System : Headache, tremor, disturbed sleep, nightmares, restlessness, muscle weakness, agitation, rigidity, movement disorder, confusion, fatigue, sleeplessness, weakness, lethargy, incoordination, slurred speech, depression, jerks and anxiety.
•   Heart : Fast heart rate, low/high blood pressure, chest pain an ECG changes.
•   Gastrointestinal : Constipation, nausea, abdominal discomfort, heartburn, vomiting, diarrhea, liver test abnormality and loss of appetite.
•   Genitourinary : Urinary abnormalities, incontinence, abnormal ejaculation, urinary urgency/frequency and urinary retention.
•   Skin : Rash.
•   Musculoskeletal : Muscle weakness/pain, muscle spasm and muscle pain.
•   Respiratory : Throat discomfort, difficulty in breathing, shortness of breath and nasal congestion.
•   Blood : Decrease in white blood cells and eosinophilia.
•   Miscellaneous : Weight gain, tongue numbness, salivation, sweating, dry mouth and visual disturbances.

What are the other precautions for Clozapine?

Avoid drinking caffeinated beverages.

What are the storage conditions of Clozapine?

Keep this medication in the container it came in and out of the reach of children.

♦ Safety Labeling Changes Approved By FDA

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Rajnikant1957 

Sir My wife has been on skizoril 25 for more than 2 years earlier she was prescribed trancodol dt . Her mood swings are wild, but not violent. Of late she has stopped eating any thing and has lost substantial weight in a fortnight. We are alarmed. What to do?

miniya 

I have been taking sizopin 100mg/50mg since last 5 years. Now sizopin has been changed to skizoril 100 mg. Please advise is there any side effetcs of any other problem due to change of this medicine...minia

arunpatel 

sir;my sister suffered schizophrenia.taking sizopin75at night and Uvox 100 mg twise.27years,53kg weight.now filling better butt here is wickness,drinks much water filling loss of energy,main problem is due to deepsleeping like unconsious urin in bed 2-3times at night.so we canchange tab sizopin? by skizoril,if so what can occour.please suggest.

genglob 

You can purchase sizopine from the following link if you are outside India.
Please check the details on how to get sizopine in India and abroad.

murali_kgf 

I have been taking Sizopin from past 7yrs under the supervision of my doctor. The dosage has been diminishing from 100mg to 25mg currently. Now i am pregnet and would like your advice whether to continue the course or to stop it?? Will it have any affects on the child about to born. Whether the new born child will also be affected like me.I have consulted my doctor but i am not convinced in her reply. Kindly suggest whether to continue the dosage or it has to be stopped.

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