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Clozapine
Updated on : January - 2012
Latest prescription information about Clozapine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Clozapine
Pronunciation : kloe' za peen
Therapeutic Classification : Psychotherapeutics
ICD Code : Y49.5
♦ Safety Labeling Changes Approved By FDA
Trade Name(s): India- Chrozap Tab, Clomach Tab, Clopaz Tab, Clopin Tab, Cozacin Tab, Lozapin Tab, Lozaril Tab, Refract Tab, Sizopin Tab, Skizoril Tab, Sloza Tab, Syclop Tab, Syzopin Tab, Zopin Tab. International- Clozaril , FazaClo. Why it is prescribed (Indications) : This medication is an antipsychotic, prescribed for schizophrenia. It changes the activity of certain natural substances in the brain. When it is not to be taken (Contraindications): Contraindicated in patients with myeloproliferative disorders (abnormal growth of blood cells), uncontrolled epilepsy, intestinal obstruction, drug-induced agranulocytosis, co-adminisered with drugs that are causing agranulocytosis and hypersensitivity.
Dosage & When it is to be taken : The initial dose is 12.5 mg two times/day, and the dose is increased by 25–50 mg each day, until the dose reaches 300–450 mg per day. The usual dosage range is 300–600 mg per day. Maximum: 900mg/day. How it should be taken : It comes as a tablet to take by mouth, with or without food. Warnings and Precautions : ♦ * Caution should be exercised in patients with history of intestinal obstruction, increased eye pressure, irregular heartbeat, QT prolongation, heart arrest, enlarged prostate, high or low blood pressure, heart, kidney, lung or liver disease, any allergy, who are taking this medications, during pregnancy and breast feeding. * Avoid alcohol consumption. * It may cause drowsiness, dizziness or lightheadedness, do not drive a car or operate machinery and get up slowly from bed while taking this medication. * Patient may develop with increased risk of agranulocytosis, high blood pressure, diabetes, monitor blood counts, blood pressure and sugar level regularly while taking this medication. * It may cause neuroleptic malignant syndrome (NMS) with the following symptoms: fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. If it so consult with your doctor. Side Effects : Central Nervous System- Drowsiness, seizures, dizziness and fainting. Heart - Fast heart rate, low blood pressure, heart arrest, and ECG changes. Gastrointestinal - Nausea and vomiting. Blood - Decrease in blood cell counts and fever. Central Nervous System - Headache, tremor, disturbed sleep, nightmares, restlessness, muscle weakness, agitation, rigidity, movement disorder, confusion, fatigue, sleeplessness, weakness, lethargy, incoordination, slurred speech, depression, jerks and anxiety. Heart - Fast heart rate, low/high blood pressure, chest pain an ECG changes. Gastrointestinal - Constipation, nausea, abdominal discomfort, heartburn, vomiting, diarrhea, liver test abnormality and loss of appetite. Genitourinary - Urinary abnormalities, incontinence, abnormal ejaculation, urinary urgency/frequency and urinary retention. Skin - Rash. Musculoskeletal - Muscle weakness/pain, muscle spasm and muscle pain. Respiratory - Throat discomfort, difficulty in breathing, shortness of breath and nasal congestion. Blood - Decrease in white blood cells and eosinophilia. Miscellaneous - Weight gain, tongue numbness, salivation, sweating, dry mouth and visual disturbances. * Avoid drinking caffeinated beverages. Storage Conditions : Keep this medication in the container it came in and out of the reach of children. |
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- Food and Drug Administration (FDA)
- National Institutes of Health (NIH)
- PubMed
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- Indian Pharma Reference Guide 2012
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