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Clofibrate

Latest prescription information about Clofibrate. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Clofibrate
Pronunciation : kloe FIB rate
Therapeutic Classification : Fibrate Drug
Trade Name(s): 
International- Atromid- S.
Why it is prescribed (Indications) : 
This medication is a dyslipidaemic agent, prescribed for hyperlipidaemia.  It lowers triglycerides and very-low-density lipoprotein (VLDL) level.
When it is not to be taken (Contraindications): 
Contraindicated in patients with known hypersensitivity, severe liver or kidney impairment, cirrhosis, during pregnancy and breastfeeding.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Initial: PO- The recommended dosage for adults is 2 g daily in divided doses.
How it should be taken : 
It comes as a capsule to take by mouth, with or without food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of peptic ulcer, underactive thyroid gland, diabetes, and who are taking other medications.
* Follow diet and exercise program regularly as directed by your physician.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Side Effects : 
Most Common - Nausea.
Gastrointestinal - Vomiting, loose stools, indigestion, flatulence, stomach inflammation and abdominal distress.
Central Nervous System - Headache, dizziness, and fatigue.
Musculoskeletal - Muscle cramping, aching and weakness.
Skin - Skin rash, hives, itching, dry brittle hair and hair loss.
Heart - Chest pain, abnormal heart rhythm, and vein inflammation.
Blood - Decrease in white blood cells, anemia and eosinophilia.
Miscellaneous - Weight gain.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at room temperature (25°C).

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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