Generic Name : Clofarabine Pronunciation : kloe-FAR-a-been Therapeutic Classification : Chemotherapy ICD Code : Y43.3♦ Safety Labeling Changes Approved By FDA
International- Clolar. Why it is prescribed (Indications) : This medication is a form of antimetabolite chemotherapy, prescribed for leukemia in children and adolescents. It kills existing cancer cells and limits the development of new cancer cells. When it is not to be taken (Contraindications): Contraindicated in patients who are taking medications that may affect kidney and liver, and hypersensitivity.
Dosage & When it is to be taken : Child- IV- The recommended dose and schedule is 52 mg/m2 over 2 hours infusion daily for 5 consecutive days. How it should be taken : It comes as a solution for injection to be administered by a healthcare provider. Warnings and Precautions :
* Caution should be exercised in patients with history of hematopoietic stem cell transplant (HSCT), low blood pressure, heart, liver or kidney disease, bone marrow depression, any allergy, who are taking other medications, during pregnancy and breast-feeding.
* It may cause drowsiness, dizziness, or blurred vision, do not drive a car or operate machinery while taking this medication.
* It may reduce platelet counts; avoid injury or bruising.
* Monitor blood counts, blood pressure, lung function, liver function, kidney function, and blood uric acid levels regularly while taking this medication. Side Effects :
Most Common - Gastrointestinal tract symptoms, including vomiting, nausea, and diarrhea.
Blood - Anemia, decrease in white blood cells and transfusion reaction.
Heart - Fast heart rate, flushing and high blood pressure.
♦ Gastrointestinal - Abdominal pain, constipation, diarrhea, gum bleeding, nausea, sore throat, vomiting, GI bleeding.
General - Fluid retention, fatigue, injection site pain, lethargy, fever and rigors.
Liver - Liver enlargement and jaundice.
Metabolic - Loss of appetite and decreased weight.
Musculoskeletal - Joint/muscle pain, back pain and pain in limb.
Central Nervous System - Dizziness, headache, drowsiness, tremor, anxiety, depression and irritability.
Genitourinary - Blood in urine.
Respiratory - Cough, difficulty in breathing, nose bleed and respiratory distress.
Skin - Contusion, skin inflammation, dry skin, redness, blister and itching.
* Avoid excess dosage. Storage Conditions :
Store it at room temperature (25°C).
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