This medication is a platinum-based chemotherapy agent, prescribed for ovarian cancer, bladder cancer and metastatic testicular tumors either alone or with other medications. It stops cancer cell growth.
Contraindicated in patients with hearing impairment, kidney impairment and hypersensitivity.
Adult: IV- Metastatic ovarian cancer As monotherapy: 100 mg/m2 per cycle, given as a single dose once every 4 week.
For combination therapy with cyclophosphamide: 75-100 mg/m2 on day 1 of every 4-week cycle. Metastatic testicular tumors 20 mg/m2/day for 5 days per cycle. Advanced bladder cancer 50-70 mg/m2 per cycle once every 3-4 week.
It comes as a solution for injection to be administered by a healthcare provider into the vein.
• Caution should be exercised in patients with history of bone marrow suppression, kidney or liver disease, any allergy, who are taking other medications, elderly, children, during pregnancy and breast-feeding.
• Monitor complete blood counts, ear and neurological functions regularly while taking this medication.
• Patients may develop with increased risk of nephrotoxicity (kidney damage with irritation), drink adequate fluids to prevent damage.
• Avoid vaccination while taking this medication.
• It may develop new type of cancer; if you have any doubt consult with your doctor regarding this.
• Toxic effects :
Nephrotoxicity (kidney damage) and ototoxicity (ear damage).
• Severe effects : Stroke, heart attack, electrolyte disturbances and allergic reactions.
• Gastrointestinal : Loss of appetite, nausea and vomiting.
• ENT : Ringing in the ear, loss of hearing and deafness.
Avoid excess dosage.
This drug is used only under the supervision of physician.
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