Cetuximab - Drug Information

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General Information on Cetuximab

Generic Name : Cetuximab

Pronunciation : seh TUX ih mab

Latest prescription information about Cetuximab. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.4 | Therapeutic Classification : Monoclonal antibodies

Trade Names/Brand Names of Cetuximab

International- Erbitux.

Why is Cetuximab Prescribed? (Indications)

This medication is a monoclonal antibody, prescribed for certain types of head, neck, and colorectal cancer.  It works by blocking a certain growth factor.

When should Cetuximab not to be taken? (Contraindications)

Hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Cetuximab?

Monotherapay- The recommended initial dose is 400 mg/m2 administered as a 120-minute intravenous infusion (maximum infusion rate 10 mg/min).
With radiation therapy- Adult- IV- The recommended initial dose is 400 mg/m2 administered one week prior to initiation of a course of radiation therapy as a 120-minute intravenous infusion (maximum infusion rate 10 mg/min). Maintenance: 250mg/m2.

How should Cetuximab be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Cetuximab?

Caution should be exercised in patients with history of abnormal blood electrolyte levels, lung or breathing problems, respiratory tract infection, heart failure, or irregular heartbeat, any allergy, who are taking other medications, children, during pregnancy and breast-feeding.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Avoid exposure to sunlight.

What are the side effects of Cetuximab?

   Most Common : Rash, itching, nail changes, headache, diarrhea and infections.
   Serious Effects : Heart arrest, kidney failure, blood clot in lungs and skin damage.
   Body as a Whole : Weakness, fever, headache, infection and chills.
   Gastrointestinal : Nausea, nosebleed, diarrhea and indigestion.
   Metabolic : Weight loss, dehydration, increase in liver enzyme levels.
   Respiratory : Inflammation of pharynx.
  Eye: Corneal ulcer.

What are the other precautions for Cetuximab?

Avoid excess dosage.

What are the storage conditions of Cetuximab?

Store it in refrigerator (2C to 8C). Do not freeze it.

♦ Safety Labeling Changes Approved By FDA

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behrooz 

Hi, I am Behrooz Farhadi master student of medical biotechnology in medical university of Tabriz from Iran. I want to know the complete DNA sequence of cetuximab for my research. Thanks a lot for your help.

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