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Cephaloridine - Indications, Dosage, Side Effects and Precautions

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Information about Cephaloridine

Generic Name : Cephaloridine
Up-to-date prescription details regarding Cephaloridine are provided here.

Pronunciation : Ce-Pha-lo-Ri-Dine

Learn the correct pronunciation of the Cephaloridine, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.


Therapeutic Classification : Antibiotics

Trade Names/Brand Names of Cephaloridine

India :

Overview of Cephaloridine

• Cephaloridine is a semisynthetic antibiotic with antibacterial activity, derived from the natural antibiotic, cephalosporin C.

Why is Cephaloridine Prescribed? (Indications)

Cephaloridine, administered parenterally was used for bacterial infections, like lower respiratory tract, skin and urinary tract infections (before 1970s). It is no longer available for therapeutic use.
Cephaloridine acts like other cephalosporin and penicillin antibiotics by interfering with the final step of bacterial cell wall synthesis. As a result the cell wall weakens and cell lysis occurs.
Cephaloridine is more commonly used in veterinary practice to treat mild to severe bacterial infections caused by penicillin resistant and penicillin sensitive bacterial species.

When should Cephaloridine not be taken? (Contraindications)

• Cephaloridine is contraindicated in patients with a history of severe allergic reactions to penicillin and cephalosporin antibiotics.
Alcohol should be avoided when taking cephaloridine.

What is the dosage of Cephaloridine?

• The recommended dose for cephaloridine is a daily dose of 1 to 3 g.
• Doses more than 4 g can prove to be nephrotoxic to the patients.

How should Cephaloridine be taken?

• Cephaloridine should be taken via intrathecal for the duration of 24 hours and via intramuscular for the duration of 12 hours.

What are the warnings and precautions for Cephaloridine?

• A daily dose of more than 4 g of cephaloridine may be toxic to the kidneys of normal patients.

• Smaller doses may damage the kidneys of patients with underlying renal disease or those receiving other nephrotoxic drugs.

• Hence patients with any known renal impairment should be monitored closely.

• Cephaloridine should not be used in patients with high levels of urea and creatinine.

What are the side effects of Cephaloridine?

• Cefaloridine has marked dose-related nephrotoxicity.
• The drug accumulates in the proximal renal tubular cell, probably by active anionic transport.
Probenecid, which blocks such transport, is given to patients to eliminate the nephrotoxicity of cephaloridine when it occurs.

• Other side effects common to first-generation cephalosporin class of antibiotics are
Diarrhea, nausea, rash, pain and inflammation at the injection site

Gastrointestinal: Pseudomembranous colitis (inflammation of the colon)
Hematological disorders: Esinophilia, low levels of prothrombin, abnormalities of blood coagulation
Nephrological disorder: Renal damage at large doses
Others: Vomiting, headache, dizziness, fungal infections of the mouth and vagina, fever

• Certain complications that maybe caused by the use of cephaloridine include seizures, coma, chronic renal failure, acute renal failure and death.

What are the other precautions for Cephaloridine?

• The entire course of this antibiotic should be completed even if the patients feel better; this will make sure the infection is cured.
• There have been instances of renal tubular necrosis with uremia and death after large doses in some patients with progressive renal disease, and toxic effects on the central nervous system after intrathecal administration.

What are the Drug Interactions of Cephaloridine?

• Cephaloridine interacts with amikacin (sulfate), ethacrynic acid, frusemide or furosemide, penicillamine, reviparin sodium and anticoagulants like acenocoumarol, dicoumarol, phenindione and phenprocoumon.

What are the storage conditions for Cephaloridine?

• The drug should be stored at 2-8°C temperature away from moisture and direct sunlight.
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