Generic Name : Cefepime Pronunciation : SEF-e-peem Therapeutic Classification : Antibiotics ICD Code : Y40.1♦ Safety Labeling Changes Approved By FDA
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International- Maxipime. Why it is prescribed (Indications) :
This medication is cephalosporin antibiotic, prescribed for certain bacterial infections. It kills sensitive bacteria. When it is not to be taken (Contraindications):
Hypersensitivity to cephalosporins.
Dosage & When it is to be taken :
IV- UTI- The recommended dose is 0.5-1 g 12 hourly for 7-10 days.
Empirical therapy for febrile neutropenia- 2 g 8 hourly for 7 days or until resolution of neutropenia. How it should be taken :
It comes as a solution for injection, administered by a healthcare provider either into a large muscle or vein over 30 minutes. Warnings and Precautions :
*Caution should be exercised in patients with history of penicillin or cephalosporin allergy, gastro intestinal disease, especially colitis; lactation, pregnancy, seizures.
*It may decrease prothrombin activity; monitor prothrombin time in patients with poor nutritional state, kidney or liver impairment and those on prolonged treatment.
*Prolonged treatment may result in overgrowth of non-susceptible organisms, resulting in superinfection.
*Consider the possibility of Clostridium difficile associated diarrhea in patients who present with diarrhea after treatment.
♦ *Patient may develop with increased risk of neurotoxicity. Side Effects :
Central Nervous System- Headache.
Gastrointestinal- Nausea, vomiting, diarrhea, inflammation of colon, including pseudomembranous colitis, oral candidiasis.
Skin- Rash, itching, hives.
Miscellaneous- Hypersensitivity, including, allergic reaction, toxic epidermal blistering, rash, inflammation or veins, pain or inflammation at injection site; fever.
*In diabetes patients - it may cause the results of some tests for urine glucose to be wrong. Becareful while changing the dose of your diabetes medicine. Storage Conditions :
Injection: In dry state: Store at 2-25°C and protected from light. After reconstitution: This solution is stable for 24 hour at controlled room temperature (2-25°C) and for 7 days under refrigeration (2-8°C).
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