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Cefepime

Updated on : September - 2012
Latest prescription information about Cefepime. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Cefepime
Pronunciation : SEF-e-peem
Therapeutic Classification : Antibiotics
ICD Code : Y40.1
Trade Name(s): 
India- Adpime Vial, Biopime Vial, Cadpime Vial, Calpime Inj, Ceficad Vial, Cefpime Vial, Cefudix Vial, Cepime Inj Vial, Cepime Vial, Chase Vial, C-Pime Inj, C-Pime-T Inj, Efepime Inj, Effimax Vial, Forpar Inj, Inpime Vial, Insipim Inj, Ipacare Vial, Ivipime Vial, Kampi Inj, Kefage Vial, Kepime Vial, Kingcef Inj Vial, Kpm-1000 Inj, Leepime Vial, Magnova 500 Vial, Magnova Vial, Mapime Vial, Maxicef Inj Vial, Maxipime Vial, Megapime Vial, Micropime Inj, Mikapime Tab, Nicpime Am Iv/Imvial, Nitipime Vial, Novapime Vial, Orpime Vial, Patriat Vial, Pimeriv Vial, Potentox Inj, Pryme Vial, Quadrocef Vial, Radipime Vial, Scud Inj Vial, Sefdin Inj Vial, Sefpin Inj, Sepin Vial, S-Pime Vial, Supime Vial, Swift Inj, Textime Vial, Ultipime Vial, Vegapime Vial, Xepime Vial, Xiopen Inj, Zwiter Vial.
International- Maxipime.
Why it is prescribed (Indications) : 
This medication is cephalosporin antibiotic, prescribed for certain bacterial infections. It kills sensitive bacteria. 
When it is not to be taken (Contraindications): 
Hypersensitivity to cephalosporins.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
IV- UTI- The recommended dose is 0.5-1 g 12 hourly for 7-10 days.
Empirical therapy for febrile neutropenia- 2 g 8 hourly for 7 days or until resolution of neutropenia.
How it should be taken : 
It comes as a solution for injection, administered by a healthcare provider either into a large muscle or vein over 30 minutes.
Warnings and Precautions : 
*Caution should be exercised in patients with history of penicillin or cephalosporin allergy, gastro intestinal disease, especially colitis; lactation, pregnancy, seizures.
*It may decrease prothrombin activity; monitor prothrombin time in patients with poor nutritional state, kidney or liver impairment and those on prolonged treatment.
*Prolonged treatment may result in overgrowth of non-susceptible organisms, resulting in superinfection.
*Consider the possibility of Clostridium difficile associated diarrhea in patients who present with diarrhea after treatment.
*Patient may develop with increased risk of neurotoxicity.
Side Effects : 
Central Nervous System- Headache.
Gastrointestinal- Nausea, vomiting, diarrhea, inflammation of colon, including pseudomembranous colitis, oral candidiasis.
Skin- Rash, itching, hives.
Miscellaneous- Hypersensitivity, including, allergic reaction, toxic epidermal blistering, rash, inflammation or veins, pain or inflammation at injection site; fever.
Other Precautions : 
*In diabetes patients - it may cause the results of some tests for urine glucose to be wrong. Becareful while changing the dose of your diabetes medicine.
Storage Conditions : 
Injection: In dry state: Store at 2-25°C and protected from light. After reconstitution: This solution is stable for 24 hour at controlled room temperature (2-25°C) and for 7 days under refrigeration (2-8°C).
♦ Safety Labeling Changes Approved By FDA

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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