Medindia » Medication Manual » Carfilzomib

Carfilzomib

Latest prescription information about Carfilzomib. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Carfilzomib
Trade Name(s): 
International- Kyprolis.
Why it is prescribed (Indications) : 
This medication is an antineoplastic agent, prescribed for multiple myeloma. It helps to slow the growth and spread of the cancer.
When it is not to be taken (Contraindications): None.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
IV- Cycle 1- The recommended dose is 20 mg/m².
If tolerated in Cycle 1, the dose should be increased to 27 mg/m² beginning in Cycle 2 and continued at 27 mg/m² in subsequent cycles.
How it should be taken : 
It comes as a powder for injection (diluted with fluid) to be administered by a healthcare provider into the vein.
Warnings and Precautions : 
* Caution should be exercised in patients with history of heart arrest, congestive heart failure, high blood pressure, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause fatigue, dizziness, fainting, and/or low blood pressure, do not drive a car or operate machinery while taking this medication.
* Patient may experience shortness of breath, if it is so consult with your healthcare provider.
Side Effects : 
Fatigue, anemia, nausea, decrease in platelets, difficulty in breathing, diarrhea, and fever.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it in refrigerator (2°C to 8°C).

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Member Comments ( 1 )
When is Kyprolis going to be available in India?
(Posted by abdriver2000, India Date : 1/15/2013 )

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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