Carbidopa-Levodopa - Drug InformationGeneric Name : Carbidopa-Levodopa | Pronunciation : kar bi doe' pa- lee voe doe' pa
International :Atamet, Parcopa, Sinemet, Stalevo
Why it is prescribed (Indications) :This combination medication contains antidyskinetic drugs, prescribed for Parkinson’s disease. The addition of Carbidopa enhances lower dose of Levodopa to be used.
When it is not to be taken (Contraindications):Contraindicated in patients with skin lesions or cancer, co-administration with MAOIs or within 14 days of MAOIs administration and hypersensitivity.
Pregnancy Category :
Category C :Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Dosage & When it is to be taken :Initial: Adult- PO- Per tab contains L-dopa 100 mg and carbidopa 25 mg. Initial: 1 tab 3 times per day. It may be increased.
How it should be taken :It comes as a capsule and tablet to take by mouth, on an empty stomach.
Warnings and Precautions :Caution should be exercised in patients with history of hormone problems, asthma, mental illness, diabetes, ulcer, heart attack, irregular heartbeat, heart, kidney, liver or lung disease, any allergy, who are taking other medications, elderly, children, during pregnancy and breast feeding.
It may cause drowsiness, dizziness or lightheadedness, do not drive a car or operate machinery while taking this medication.
Avoid alcohol consumption.
It may cause mental or mood changes; if it is so consult with your doctor.
Patient may develop with increased risk of Neuroleptic Malignant Syndrome with the following symptoms: fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat and sweating. If it is so consult with your doctor.
Monitor complete blood cell counts and liver function regularly while taking this medication.
Side Effects :
Most common - Involuntary movements and nausea.
Body as a Whole - Chest pain and weakness.
Heart - Irregular heart beat, low/high blood pressure, fainting, vein inflammation and palpitations.
Gastrointestinal - Dark saliva, stomach bleeding, development of duodenal ulcer, loss of appetite, vomiting, diarrhea, constipation, indigestion, dry mouth and taste alterations.
Blood - Anemia, decrease in white blood cells and platelets.
Hypersensitivity - Shock, hives, itching, bruising and lesions.
Musculoskeletal - Back pain, shoulder pain and muscle cramps.
Central Nervous System- Hallucinations, confusion, agitation, dizziness, drowsiness, abnormal dreams, sleeplessness, tingling, headache, depression, suicidal tendencies, dementia and increased sexual drive.
Respiratory - Difficulty in breathing and upper respiratory infection.
Skin - Rash, increased sweating, hair loss and increased sweating.
Genitourinary - Urinary tract infection, urinary frequency and dark colored urine.