Carbamazepine - Drug Information

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General Information on Carbamazepine

Generic Name : Carbamazepine

Pronunciation : kar ba maz' e peen

Latest prescription information about Carbamazepine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y46.6 | Therapeutic Classification : Anticonvulsants

Why is Carbamazepine Prescribed? (Indications)

This medication is an anticonvulsant drug, prescribed for epilepsy and bipolar disorder, as well as trigeminal neuralgia.  It works by reducing or blocking certain responses in the brain.

When should Carbamazepine not to be taken? (Contraindications)

Contraindicated in patients with bone marrow depression, co administration with nefazodone, MAOIs or within last 14 days and hypersensitivity.

Pregnancy Category

A B C D X

Category D :

There is an evidence of fetal risk based on adverse reaction data, but potential benefits may allow the drug to be used in pregnant women despite risks.

What is the dosage of Carbamazepine?

Adult: PO Epilepsy Initial: 100-200 mg 1-2 times/day, may increase slowly. Maintenance: 0.8-1.2 g/day in divided doses. Max: 2 g/day.
Prophylaxis of bipolar disorder Initial: 400 mg/day in divided doses may increase slowly. Maintenance: 400-600 mg/day. Max: 1.6 g/day.
Trigeminal neuralgia Initial: 100 mg 1-2 times/day, may increase slowly. Maintenance: 400-800 mg/day in 2-4 divided doses. Max: 1.2 g/day.
Rectal Epilepsy -250 mg 6 hourly.
Children 6-12 years of age – Initial- Either 100 mg b.i.d. for tablets or XR tablets, or ½ teaspoon q.i.d. for suspension (200 mg/day).
Children 6 years of age – Initial- 10-20 mg/kg/day b.i.d. or t.i.d. as tablets, or q.i.d. as suspension.

How should Carbamazepine be taken?

It comes as a capsule to take by mouth, with food.

What are the warnings and precautions for Carbamazepine?

• Caution should be exercised in patients with history of increased eye pressure, psychosis, heart, kidney, thyroid or liver diseases, mood or mental problems, suicidal thoughts, seizures, any allergy, who are taking other medications, elderly, children, during pregnancy and breast feeding.
• It may cause drowsiness, dizziness or blurred vision, do not drive a car or operate machinery while taking this medication.
• Avoid alcohol consumption.
• Patients may develop with increased risk of suicidal thoughts, watch them carefully.
• Avoid changing the medication form (tablet to suspension) without healthcare provider’s advice.
• It may decrease the effect of hormonal birth control pills; use other methods to prevent pregnancy.

What are the side effects of Carbamazepine?

•   Most frequent : Dizziness, drowsiness, unsteadiness, nausea and vomiting.
•   Blood : Anemia, decrease in blood cell counts and bruising.
•   Skin : Skin disorder, itching, redness, rash, hives, photosensitivity reactions, pigmentation, inflammation, hair loss, increased sweating and Onychomadesis.
•   Heart : Congestive heart failure, swelling, high/low blood pressure, fainting, collapse, vein inflammation, blood clots in vein and swollen glands.
•   Liver: Abnormalities in liver function tests, jaundice and liver inflammation.
•   Respiratory : Fever, diffculty in breathing or pneumonia due to allergic reactions.
•   Genitourinary : Urinary frequency, urinary retention, elevation of blood urea nitrogen (BUN), kidney failure and impotence.
•   Gastrointestinal : Abdominal pain, diarrhea, constipation, loss of appetite, dryness of the mouth and pharynx and mouth ulcer.

What are the other precautions for Carbamazepine?

Avoid contact with people with any infection.
It may reduce platelet counts, avoid injury or bruising.
Avoid exposure to sunlight; otherwise it may lead to sunburn.

What are the storage conditions of Carbamazepine?

Store it at room temperature.

♦ Safety Labeling Changes Approved By FDA

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balan473 

I am taking mazetol 200 one at night for the last 5 years. how much time more I should take this medicine. what are the side effects of this tab

Arjunkumarmahto 

i am taking zen retard 300 mg [2-tablet per day] since last 5 years and i am 25 years old. i want to know what is the most side effect of this medicine. I think i am loosing my weight is it cause of taking this medicine

tp360 

Iam taking zen200 since 17 yrs,1 tab in mrng 1 tab in afternoon,1and half in night,iam advised to continue the same dosage until death,pls explain the probable side effects.

zen-200 

what is the relation between carbamazepine long term use and cancer

Prabha_Petwal 

I take zen100 daily once in night, is it risky, if yes what test I should do,to know that every thing is going right,pls suggest me some test.

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