Busulphan - Drug Information

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General Information on Busulphan

Generic Name : Busulphan

Pronunciation : byoo sul' fan

Latest prescription information about Busulphan. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Busulphan

India- Bucelon Amp, Bucelon Film-Coated Tab, Busulfan Tab , Busuphan Tab, Mylefan Tab, Myleran Tab , Myran Tab , Mysulfan Tab.
International- Busulfex.

Why is Busulphan Prescribed? (Indications)

This medication is a chemotherapy agent, prescribed for chronic myelogenous leukemia. It is also used for bone marrow transplantation. It slows or stops the growth of cancer cells.

When should Busulphan not to be taken? (Contraindications)

Hypersensitivity.

Pregnancy Category

A B C D X

Category D :

There is an evidence of fetal risk based on adverse reaction data, but potential benefits may allow the drug to be used in pregnant women despite risks.

What is the dosage of Busulphan?

Adult: PO- Palliation of chronic myeloid leukaemia- 60 mcg/kg/day. Maintenance: 0.5-2 mg/day. Max: 4 mg/day.

How should Busulphan be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Busulphan?

Caution should be exercised in patients with history of bone marrow depression, blood problems, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Avoid alcohol consumption.
Avoid vaccination.
Monitor blood counts, sugar level regularly during therapy.
It may cause lung toxicity; if so stop the medication.
It may cause infertility, consult with your doctor for any queries.

What are the side effects of Busulphan?

   Body As A Whole : Fever, headache, weakness, chills, pain, swelling, general allergic reactions, chest pain, inflammation at injection site and back pain.
   Heart : Fast heart rate and dilatation of blood cells.
   Gastrointestinal : Nausea, mouth ulcer, vomiting, loss of appetite, diarrhea, abdominal pain, indigestion, constipation, dry mouth, rectal disorder and abdominal enlargement.
   Metabolic : Decrease in magnesium/glucose/potassium/calcium and increase in liver enzyme levels.
   Central Nervous System : Sleeplessness, anxiety, dizziness and depression.
   Respiratory : Nose inflammation, lung disorder, cough, nosebleed and difficulty in breathing.
   Skin : Rash and itching.

What are the other precautions for Busulphan?

It may cause ovarian failure and may stop girls from reaching puberty.

What are the storage conditions of Busulphan?

Store it at room temperature and away from excess heat and moisture. Keep away from children.


Schedule : G

Drugs that are to be used only under medical supervision.

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