Generic Name : Buserelin Pronunciation : bue-se-REL-in Therapeutic Classification : Chemotherapy ICD Code : Y43.3
International- Suprefact CinnaFact, Metrelef. Why it is prescribed (Indications) :
This medication is a gonadotropin-releasing hormone agonist, prescribed for prostate cancer and breast cancer. It controls the release of eggs from ovaries by stopping the production of natural hormones. When it is not to be taken (Contraindications):
Contraindicated in patients with hormone-dependent tumors, pituitary adenoma, weight-related amenorrhoea (absence of menstrual period).
Dosage & When it is to be taken :
SC- Advanced prostate carcinoma- Initial: 500 mcg 8 hourly for 7 days. Maintenance: 200 mcg once daily. Depot 6.3 mg implant 8 weekly or 9.45 mg 12 weekly.
Pituitary desensitisation before ovulation induction with gonadotrophins- 200-500 mcg/day until pituitary downregulation occurs, usually for 1-3 week.
Pituitary desensitisation before ovulation induction with gonadotrophins- 150 mcg 4 times/day beginning on day 1 or day 21 of the menstrual cycle until pituitary downregulation occurs, usually for 1-3 weeks.
For nasal dosage forms: Adults: 200 micrograms (mcg) (2 sprays) into each nostril every eight hours. How it should be taken :
It comes as a solution for injection to be administered by a healthcare provider under the skin. Warnings and Precautions :
* Caution should be exercised in patients with history of high blood pressure, diabetes, depression, polycystic ovarian disease, during pregnancy and breastfeeding.
* Avoid use of nasal decongestants before and at least 30 min after treatment.
* Men at risk from tumor flare. Side Effects :
Central Nervous System - Headache, lightheadedness, mood changes and nervousness.
Heart - Palpitations.
Skin - Pimples, dry skin, itching, allergic reactions, changes in scalp and body hair.
Musculoskeletal - Tumor flare (may manifest as increase in bone pain) and spinal cord compression.
Genitourinary - Women- Worsening of urinary tract symptoms, blood in urine, increase in menstrual bleeding, urinary obstruction, vaginal dryness, hot flushes, loss of libido and osteoporosis.
Men- Hot flushes, breast swelling, tenderness and sexual dysfunction.
* Avoid excess dosage. Storage Conditions :
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
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