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Bretylium Tosylate Injection

Latest prescription information about Bretylium Tosylate Injection. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Bretylium Tosylate Injection
Pronunciation : breh-TILL-ee-uhm TAH-sill-ate
Therapeutic Classification : Antiarrhythmics
ICD Code : Y52.2
Trade Name(s): 
International- Bretylium.
Why it is prescribed (Indications) : 
This medication is an antiarrhythmic agent, prescribed for ventricular fibrillation and life-threatening ventricular arrhythmia. It blocks the release of noradrenaline from nerve system.
When it is not to be taken (Contraindications): 
Hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Life-Threatening Ventricular Arrhythmias- Adults- IV- The recommended dose is 5 to 10 mg/kg.
Children- IV- 50mg/kg/dose followed by 10mg/kg at 10 to 30 min intervals.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider.
Warnings and Precautions : 
* Caution should be exercised in patients with history of low or high blood pressure, severe heart disease, blocked blood vessels, lung, liver or kidney disease, children, during pregnancy and breastfeeding.
* It may cause dizziness and lightheadedness, get up slowly from bed.
Side Effects : 
Heart - Low blood pressure, slow heart rate, increased premature ventricular contractions and abnormal heart rhythm, high blood pressure, chest pain and sensation of substernal pressure.
Central Nervous System - Dizziness, lightheadedness, fainting, anxiety and vertigo.
Gastrointestinal - Nausea and vomiting after rapid IV injection, diarrhea and abdominal pain.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at room temperature (25°C).

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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