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Boceprevir

Updated on : July - 2012
Latest prescription information about Boceprevir. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Boceprevir
Therapeutic Classification : Antivirals
ICD Code : Y41.5
Trade Name(s): 
International- Victrelis.
Why it is prescribed (Indications) : 
This medication is a protease inhibitor, prescribed for chronic hepatitis C. It decreases the amount of hepatitis C virus (HCV) in the body.
When it is not to be taken (Contraindications): 
Contraindicated in pregnant women, co-administration with drugs highly dependent on CYP3A4/5, Adrenoreceptor antagonist, Anticonvulsants, Ergot derivatives, HMG-CoA reductase inhibitors, PDE5 enzyme Inhibitor, Sedative/Hypnotics, St. John's Wort, rifampin, cisapride, and in people with known hypersensitivity.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
Adult- PO- The recommended dose is 800 mg (four 200-mg capsules) three times daily (every 7-9 hours) with food.
How it should be taken : 
It comes as a capsule to take by mouth, with food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of HIV/AIDS, liver or kidney impairment, Hepatitis B, cirrhosis, organ transplantation, anemia, children, during pregnancy and breastfeeding.
Side Effects : 
Most Common - Fatigue, anemia, nausea/vomiting, headache, and sensory loss.
Blood - Decrease in white blood cells and anemia.
Gastrointestinal - Taste disorders, diarrhea and dry mouth.
General - Fatigue, chills and weakness.
Metabolic - Decreased appetite.
Musculoskeletal - Joint pain.
Central Nervous System - Dizziness, sleeplessness and irritability.
Respiratory - Difficulty in breathing.
Skin - Hair loss, dry skin, rash, angioedema, and urticaria.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it in refrigerator (2-8°C). Do not freeze it.
♦ Safety Labeling Changes Approved By FDA

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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